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» Authors » Jeffrey P Froehlich

Jeffrey P Froehlich

Explore the profile of Jeffrey P Froehlich including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 177
Followers 0
Related Specialties
Biochemistry
Cardiology & Vascular Diseases
Science
Top 10 Co-Authors
James E Mahaney
Carlo G Tocchetti
David A Kass
Nazareno Paolocci
Jason R Waggoner
David D Thomas
John P Toscano
R Wayne Albers
David A Wink
Carlota Sumbilla
Published In
Biochemistry
Ann N Y Acad Sci
Circ Res
Affiliations
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Recent Articles
1.
Phospholamban thiols play a central role in activation of the cardiac muscle sarcoplasmic reticulum calcium pump by nitroxyl
Froehlich J, Mahaney J, Keceli G, Pavlos C, Goldstein R, Redwood A, et al.
Biochemistry . 2008 Dec; 47(50):13150-2. PMID: 19053265
Nitroxyl (HNO) donated by Angeli's salt activates uptake of Ca(2+) by the cardiac SR Ca(2+) pump (SERCA2a). To determine whether HNO achieves this by a direct interaction with SERCA2a or...
2.
Intermolecular interactions in the mechanism of skeletal muscle sarcoplasmic reticulum Ca(2+)-ATPase (SERCA1): evidence for a triprotomer
Mahaney J, Thomas D, Farrance I, Froehlich J
Biochemistry . 2008 Dec; 47(51):13711-25. PMID: 19046074
Native membrane sarcoplasmic reticulum (SR) Ca(2+)-ATPase isolated from skeletal muscle (SERCA1) exhibits oligomeric kinetic behavior [Mahaney, J. E., Thomas, D. D., and Froehlich, J. P. (2004) Biochemistry 43, 4400-4416]. In...
3.
Phospholamban inhibits Ca-ATPase conformational changes involving the E2 intermediate
Waggoner J, Huffman J, Froehlich J, Mahaney J
Biochemistry . 2007 Jan; 46(7):1999-2009. PMID: 17261028
We have used steady-state fluorescence spectroscopy in combination with enzyme kinetic assays to test the hypothesis that phospholamban (PLB) stabilizes the Ca-ATPase in the E2 intermediate state. The cardiac muscle...
4.
Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling
Tocchetti C, Wang W, Froehlich J, Huke S, Aon M, Wilson G, et al.
Circ Res . 2006 Dec; 100(1):96-104. PMID: 17138943
Heart failure remains a leading cause of morbidity and mortality worldwide. Although depressed pump function is common, development of effective therapies to stimulate contraction has proven difficult. This is thought...
5.
Intermolecular conformational coupling and free energy exchange enhance the catalytic efficiency of cardiac muscle SERCA2a following the relief of phospholamban inhibition
Mahaney J, Albers R, Waggoner J, Kutchai H, Froehlich J
Biochemistry . 2005 May; 44(21):7713-24. PMID: 15909986
Activation of cardiac muscle sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) by beta1-agonists involves cAMP- and PKA-dependent phosphorylation of phospholamban (PLB), which relieves the inhibitory effects of PLB on SERCA2a. To investigate the...
6.
The time-dependent distribution of phosphorylated intermediates in native sarcoplasmic reticulum Ca2+-ATPase from skeletal muscle is not compatible with a linear kinetic model
Mahaney J, Thomas D, Froehlich J
Biochemistry . 2004 Apr; 43(14):4400-16. PMID: 15065885
Quenched-flow mixing was used to characterize the kinetic behavior of the intermediate reactions of the skeletal muscle sarcoplasmic reticulum (SR) Ca-ATPase (SERCA1) at 2 and 21 degrees C. At 2...
7.
Phospholamban inhibits Ca2+ pump oligomerization and intersubunit free energy exchange leading to activation of cardiac muscle SERCA2a
Mahaney J, Albers R, Kutchai H, Froehlich J
Ann N Y Acad Sci . 2003 May; 986:338-40. PMID: 12763844
No abstract available.