James E Korkola
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Explore the profile of James E Korkola including associated specialties, affiliations and a list of published articles.
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58
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2340
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Recent Articles
1.
Jokela T, Dane M, Smith R, Devlin K, Shalabi S, Lopez J, et al.
Cell Signal
. 2023 Nov;
113:110958.
PMID: 37935340
Microenvironment signals are potent determinants of cell fate and arbiters of tissue homeostasis, however understanding how different microenvironment factors coordinately regulate cellular phenotype has been experimentally challenging. Here we used...
2.
Yu K, Basu A, Yau C, Wolf D, Goodarzi H, Bandyopadhyay S, et al.
Front Oncol
. 2023 Jun;
13:1192208.
PMID: 37384294
Introduction: Drug resistance is a major obstacle in cancer treatment and can involve a variety of different factors. Identifying effective therapies for drug resistant tumors is integral for improving patient...
3.
Hernandez S, Lim R, Onur T, Dane M, Smith R, Wang K, et al.
Hum Mol Genet
. 2022 Dec;
32(9):1483-1496.
PMID: 36547263
Astrocytes and brain endothelial cells are components of the neurovascular unit that comprises the blood-brain barrier (BBB) and their dysfunction contributes to pathogenesis in Huntington's disease (HD). Defining the contribution...
4.
Bicocca V, Phillips K, Fischer D, Caruso V, Goudarzi M, Garcia-Ransom M, et al.
J Clin Med
. 2022 Oct;
11(19).
PMID: 36233691
The clinical standard of care for urothelial carcinoma (UC) relies on invasive procedures with suboptimal performance. To enhance UC treatment, we developed a urinary comprehensive genomic profiling (uCGP) test, UroAmplitude,...
5.
Gross S, Dane M, Smith R, Devlin K, McLean I, Derrick D, et al.
Commun Biol
. 2022 Oct;
5(1):1066.
PMID: 36207580
The phenotype of a cell and its underlying molecular state is strongly influenced by extracellular signals, including growth factors, hormones, and extracellular matrix proteins. While these signals are normally tightly...
6.
Hunt G, Dane M, Korkola J, Heiser L, Gagnon-Bartsch J
Bioinformatics
. 2022 Sep;
38(21):4934-4940.
PMID: 36063034
Motivation: High-throughput fluorescent microscopy is a popular class of techniques for studying tissues and cells through automated imaging and feature extraction of hundreds to thousands of samples. Like other high-throughput...
7.
Tatarova Z, Blumberg D, Korkola J, Heiser L, Muschler J, Schedin P, et al.
Nat Biotechnol
. 2022 Jul;
40(12):1823-1833.
PMID: 35788566
Systematically identifying synergistic combinations of targeted agents and immunotherapies for cancer treatments remains difficult. In this study, we integrated high-throughput and high-content techniques-an implantable microdevice to administer multiple drugs into...
8.
Jiang H, Muir R, Gonciarz R, Olshen A, Yeh I, Hann B, et al.
J Exp Med
. 2022 Mar;
219(4).
PMID: 35262628
KRAS mutations drive a quarter of cancer mortality, and most are undruggable. Several inhibitors of the MAPK pathway are FDA approved but poorly tolerated at the doses needed to adequately...
9.
Liu M, Smith R, Liby T, Chiotti K, Lopez C, Korkola J
Breast Cancer Res
. 2022 Mar;
24(1):18.
PMID: 35248133
Background: Resistance to HER2-targeted therapeutics remains a significant clinical problem in HER2+ breast cancer patients with advanced disease. This may be particularly true for HER2+ patients with basal subtype disease,...
10.
Hunt G, Dane M, Korkola J, Heiser L, Gagnon-Bartsch J
J Comput Graph Stat
. 2021 Sep;
29(4):929-941.
PMID: 34531645
Proper data transformation is an essential part of analysis. Choosing appropriate transformations for variables can enhance visualization, improve efficacy of analytical methods, and increase data interpretability. However determining appropriate transformations...