James E Klaunig
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Explore the profile of James E Klaunig including associated specialties, affiliations and a list of published articles.
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113
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2960
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Recent Articles
1.
Elmore S, Berry C, Bolon B, Boorman G, Bradley A, Cohen S, et al.
Hum Exp Toxicol
. 2025 Jan;
44:9603271241269020.
PMID: 39884676
Managing conflicts of interest (COIs) in scientific decision-making is important for minimizing bias and fostering public trust in science. Proper management of COIs has added significance when scientists are making...
2.
Klaunig J, Cohen S
Crit Rev Toxicol
. 2024 Jul;
54(9):634-658.
PMID: 39077834
Dieldrin is an organochlorine insecticide that was widely used until 1970 when its use was banned because of its liver carcinogenicity in mice. Several long-term rodent bioassays have reported dieldrin...
3.
Ndeke J, Klaunig J, Commodore S
J Environ Expo Assess
. 2024 Jun;
3(1).
PMID: 38840831
Electronic nicotine delivery systems (ENDS) - which include electronic cigarettes or e-cigarettes, or simply e-cigs, and marijuana vaping have become increasingly popular. ENDS devices have been established as one of...
4.
Klaunig J, Bevan C, Gollapudi B
Toxicol Ind Health
. 2024 Mar;
40(5):272-291.
PMID: 38523547
Perchloroethylene (PCE) is used as a solvent and chemical intermediate. Following chronic inhalation exposure, PCE selectively induced liver tumors in mice. Understanding the mode of action (MOA) for PCE carcinogenesis...
5.
Li X, Wang Z, Wu Q, Klaunig J
J Environ Sci Health C Toxicol Carcinog
. 2024 Mar;
42(3):189-213.
PMID: 38494990
The mode of action (MOA) underlying perfluorooctanoic acid (PFOA)-induced liver tumors in rats is proposed to involve peroxisome proliferator-activated receptor α (PPARα) agonism. Despite clear PPARα activation evidence in rodent...
6.
Chen Q, Zhou Y, Ji C, Klaunig J, Shao K
Environ Health Perspect
. 2023 Dec;
131(12):127022.
PMID: 38157272
Background: Traditional dose-response assessment applies different low-dose extrapolation methods for cancer and noncancer effects and assumes that all carcinogens are mutagenic unless strong evidence suggests otherwise. Additionally, primarily focusing on...
7.
Burgoon L, Borgert C, Fuentes C, Klaunig J
Arch Toxicol
. 2023 Dec;
98(1):327-334.
PMID: 38059960
The kinetically-derived maximal dose (KMD) is defined as the maximal external dose at which kinetics are unchanged relative to lower doses, e.g., doses at which kinetic processes are not saturated....
8.
Zhou Y, Chen Q, Klaunig J, Shao K
Toxicol Sci
. 2023 Aug;
196(2):250-260.
PMID: 37643630
A main function of dose-response assessment is to estimate a "safe" dose in the target population to support chemical risk assessment. Typically, a "safe" dose is developed differently for cancer...
9.
Chen C, Yang K, Nan H, Unverzagt F, McClure L, Irvin M, et al.
Am J Alzheimers Dis Other Demen
. 2023 Jun;
38:15333175231175797.
PMID: 37340856
Introduction: We examined the associations of baseline telomere length (TL) and TL change with cognitive function over time in older US adults, as well as differences by sex and race....
10.
Cohen S, Bevan C, Gollapudi B, Klaunig J
J Toxicol Environ Health B Crit Rev
. 2023 Jun;
26(6):342-370.
PMID: 37282619
Carbon tetrachloride (CCl) has been extensively used and reported to produce toxicity, most notably involving the liver. Carbon tetrachloride metabolism involves CYP450-mediated bioactivation to trichloromethyl and trichloromethyl peroxy radicals, which...