James C Errey
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Explore the profile of James C Errey including associated specialties, affiliations and a list of published articles.
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41
Citations
1646
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Recent Articles
1.
Brown A, Bradley S, Marshall F, Brown G, Bennett K, Brown J, et al.
Cell
. 2021 Nov;
184(24):5886-5901.e22.
PMID: 34822784
Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative...
2.
Errey J, Fiez-Vandal C
Protein Expr Purif
. 2020 Jan;
169:105569.
PMID: 31945417
Whereas membrane proteins make up ∼23% of the human proteome, it is estimated that membrane proteins constitute more than 60% of current drug targets. With membrane proteins forming such a...
3.
Rappas M, Ali A, Bennett K, Brown J, Bucknell S, Congreve M, et al.
J Med Chem
. 2019 Dec;
63(4):1528-1543.
PMID: 31860301
The orexin system, which consists of the two G protein-coupled receptors OX and OX, activated by the neuropeptides OX-A and OX-B, is firmly established as a key regulator of behavioral...
4.
OBrien A, Andrews S, Baig A, Bortolato A, Brown A, Brown G, et al.
Bioorg Med Chem Lett
. 2019 Aug;
29(20):126611.
PMID: 31447084
A series of novel allosteric antagonists of the GLP-1 receptor (GLP-1R), exemplified by HTL26119, are described. SBDD approaches were employed to identify HTL26119, exploiting structural understanding of the allosteric binding...
5.
Christopher J, Orgovan Z, Congreve M, Dore A, Errey J, Marshall F, et al.
J Med Chem
. 2018 Feb;
62(1):207-222.
PMID: 29455526
Two interesting new X-ray structures of negative allosteric modulator (NAM) ligands for the mGlu receptor, M-MPEP (3) and fenobam (4), are reported. The new structures show how the binding of...
6.
Rucktooa P, Cheng R, Segala E, Geng T, Errey J, Brown G, et al.
Sci Rep
. 2018 Jan;
8(1):41.
PMID: 29311713
Here we report an efficient method to generate multiple co-structures of the A G protein-coupled receptor (GPCR) with small-molecules from a single preparation of a thermostabilised receptor crystallised in Lipidic...
7.
Dadova J, Wu K, Isenegger P, Errey J, Bernardes G, Chalker J, et al.
ACS Cent Sci
. 2017 Dec;
3(11):1168-1173.
PMID: 29202018
Biomimicry valuably allows the understanding of the essential chemical components required to recapitulate biological function, yet direct strategies for evaluating the roles of amino acids in proteins can be limited...
8.
Cheng R, Segala E, Robertson N, Deflorian F, Dore A, Errey J, et al.
Structure
. 2017 Jul;
25(8):1275-1285.e4.
PMID: 28712806
The adenosine A and A receptors belong to the purinergic family of G protein-coupled receptors, and regulate diverse functions of the cardiovascular, respiratory, renal, inflammation, and CNS. Xanthines such as...
9.
Jazayeri A, Rappas M, Brown A, Kean J, Errey J, Robertson N, et al.
Nature
. 2017 Jul;
548(7665):122.
PMID: 28700581
This corrects the article DOI: 10.1038/nature22800.
10.
Jazayeri A, Rappas M, Brown A, Kean J, Errey J, Robertson N, et al.
Nature
. 2017 Jun;
546(7657):254-258.
PMID: 28562585
Glucagon-like peptide 1 (GLP-1) regulates glucose homeostasis through the control of insulin release from the pancreas. GLP-1 peptide agonists are efficacious drugs for the treatment of diabetes. To gain insight...