James B Stewart
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Explore the profile of James B Stewart including associated specialties, affiliations and a list of published articles.
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43
Citations
2291
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Recent Articles
1.
Barrera-Paez J, Bacman S, Balla T, Van Booven D, Gannamedi D, Stewart J, et al.
Sci Transl Med
. 2025 Jan;
17(783):eadr0792.
PMID: 39879319
Primary mitochondrial disorders are most often caused by deleterious mutations in the mitochondrial DNA (mtDNA). Here, we used a mitochondrial DddA-derived cytosine base editor (DdCBE) to introduce a compensatory edit...
2.
Bernardino Gomes T, Vincent A, Menger K, Stewart J, Nicholls T
Biochem J
. 2024 May;
481(11):683-715.
PMID: 38804971
Human mitochondria possess a multi-copy circular genome, mitochondrial DNA (mtDNA), that is essential for cellular energy metabolism. The number of copies of mtDNA per cell, and their integrity, are maintained...
3.
Bacman S, Barrera-Paez J, Pinto M, Van Booven D, Stewart J, Griswold A, et al.
Mol Ther Nucleic Acids
. 2024 Feb;
35(1):102132.
PMID: 38404505
Mutations within mtDNA frequently give rise to severe encephalopathies. Given that a majority of these mtDNA defects exist in a heteroplasmic state, we harnessed the precision of mitochondrial-targeted TALEN (mitoTALEN)...
4.
High-throughput single-cell analysis reveals progressive mitochondrial DNA mosaicism throughout life
Glynos A, Bozhilova L, Frison M, Burr S, Stewart J, Chinnery P
Sci Adv
. 2023 Oct;
9(43):eadi4038.
PMID: 37878704
Heteroplasmic mitochondrial DNA (mtDNA) mutations are a major cause of inherited disease and contribute to common late-onset human disorders. The late onset and clinical progression of mtDNA-associated disease is thought...
5.
Jarvinen E, Suomi F, Stewart J, Guala D, Valori M, Jansson L, et al.
Clin Exp Immunol
. 2023 Oct;
214(3):304-313.
PMID: 37860849
Cladribine tablets are a treatment for multiple sclerosis with effects on lymphocytes, yet its mode of action has not been fully established. Here, we analyzed the effects of cladribine on...
6.
Burr S, Klimm F, Glynos A, Prater M, Sendon P, Nash P, et al.
Cell
. 2023 Feb;
186(6):1212-1229.e21.
PMID: 36827974
Mitochondrial activity differs markedly between organs, but it is not known how and when this arises. Here we show that cell lineage-specific expression profiles involving essential mitochondrial genes emerge at...
7.
Muthye V, Mackereth C, Stewart J, Lavrov D
DNA Repair (Amst)
. 2022 Jan;
110:103273.
PMID: 35066390
All studied octocoral mitochondrial genomes (mt-genomes) contain a homologue of the Escherichia coli mutS gene, a member of a gene family encoding proteins involved in DNA mismatch repair, other types...
8.
Zhang H, Esposito M, Pezet M, Aryaman J, Wei W, Klimm F, et al.
Sci Adv
. 2021 Dec;
7(50):eabi5657.
PMID: 34878831
Heteroplasmic mitochondrial DNA (mtDNA) mutations are a common cause of inherited disease, but a few recurrent mutations account for the vast majority of new families. The reasons for this are...
9.
Basu S, Xie X, Uhler J, Hedberg-Oldfors C, Milenkovic D, Baris O, et al.
PLoS Genet
. 2020 Dec;
16(12):e1009242.
PMID: 33315859
Deletions and duplications in mitochondrial DNA (mtDNA) cause mitochondrial disease and accumulate in conditions such as cancer and age-related disorders, but validated high-throughput methodology that can readily detect and discriminate...
10.
Mulder H, Stewart J, Blue I, Krakowiak R, Patterson J, Karin K, et al.
Inhal Toxicol
. 2020 Nov;
32(13-14):447-455.
PMID: 33140978
Introduction: Electronic cigarettes (e-cigarettes) have rapidly evolved since their introduction to the U.S. market. The rebuildable atomizer (RBA) offers user-driven modification to the heating element (coil) and wicking systems. Different...