James A MacLean 2nd
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Explore the profile of James A MacLean 2nd including associated specialties, affiliations and a list of published articles.
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34
Citations
1010
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Recent Articles
1.
Shi M, Oh Y, Mitchell D, MacLean J, MacLean 2nd J, McLaughlin R, et al.
bioRxiv
. 2025 Mar;
PMID: 40060613
The use of cannabis during pregnancy and nursing is a growing public health concern, and the multigenerational impacts of perinatal cannabis exposure remain largely unknown. To address this knowledge gap,...
2.
Harvey M, Shi M, Oh Y, Mitchell D, Slayden O, MacLean 2nd J, et al.
bioRxiv
. 2025 Feb;
PMID: 39896574
Introduction: Endometriosis is an inflammatory disease associated with chronic pelvic pain (CPP). Growing evidence indicates that endometriotic lesions are not the sole source of pain. Instead, central nervous system (CNS)...
3.
Zhao L, Shi M, Winuthayanon S, MacLean 2nd J, Hayashi K
bioRxiv
. 2024 Dec;
PMID: 39713385
Background: Exposure to endocrine-disrupting chemicals (EDCs), such as bisphenol A (BPA), disrupts reproduction across generations. Germ cell epigenetic alterations are proposed to bridge transgenerational reproductive defects resulting from EDCs. Previously,...
4.
Shi M, MacLean 2nd J, Hayashi K
Front Immunol
. 2024 Aug;
15:1396000.
PMID: 39192982
Endometriosis is a chronic inflammatory disease that causes debilitating pelvic pain in women. Macrophages are considered to be key players in promoting disease progression, as abundant macrophages are present in...
5.
Douglas J, Sekulovski N, Arreola M, Oh Y, Hayashi K, MacLean 2nd J
Genes (Basel)
. 2024 May;
15(5).
PMID: 38790245
Insulin receptor signaling promotes cell differentiation, proliferation, and growth which are essential for oocyte maturation, embryo implantation, endometrial decidualization, and placentation. The dysregulation of insulin signaling in women with metabolic...
6.
Herup-Wheeler T, Shi M, Harvey M, Talwar C, Kommagani R, MacLean 2nd J, et al.
Front Endocrinol (Lausanne)
. 2024 Apr;
15:1336496.
PMID: 38559689
Immune dysfunction is one of the central components in the development and progression of endometriosis by establishing a chronic inflammatory environment. Western-style high-fat diets (HFD) have been linked to greater...
7.
Herup-Wheeler T, Shi M, Harvey M, Talwar C, Kommagani R, MacLean 2nd J, et al.
bioRxiv
. 2023 Nov;
PMID: 38014254
Immune dysfunction is one of the central components in the development and progression of endometriosis by establishing a chronic inflammatory environment. Western-style high-fat diets (HFD) have been linked to greater...
8.
Zhao L, Shi M, Winuthayanon S, MacLean 2nd J, Hayashi K
Commun Biol
. 2022 Nov;
5(1):1225.
PMID: 36369244
Due to the vital roles of macrophages in the pathogenesis of endometriosis, targeting macrophages could be a promising therapeutic direction. Here, we investigated the efficacy of niclosamide for the resolution...
9.
MacLean 2nd J, Hayashi K
Cells
. 2022 Feb;
11(4).
PMID: 35203298
Estrogen and progesterone and their signaling mechanisms are tightly regulated to maintain a normal menstrual cycle and to support a successful pregnancy. The imbalance of estrogen and progesterone disrupts their...
10.
Shi M, Sekulovski N, Whorton A, MacLean 2nd J, Greaves E, Hayashi K
FASEB J
. 2021 Apr;
35(5):e21584.
PMID: 33860549
Endometriosis, a common gynecological disease, causes chronic pelvic pain and infertility in women of reproductive age. Due to the limited efficacy of current therapies, a critical need exists to develop...