James A Loehr
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Explore the profile of James A Loehr including associated specialties, affiliations and a list of published articles.
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12
Citations
310
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Recent Articles
1.
Loehr J, Latchman H, Murphy R, Cully T
Methods Mol Biol
. 2024 Dec;
2894:151-161.
PMID: 39699817
Using total protein lysates for Western blotting confers greater benefits than traditional approaches that use fractionated samples, where a portion of the sample is discarded during processing. By incorporating low-volume...
2.
Lucas L, Nitschke L, Nguyen B, Loehr J, Rodney G, Cooper T
iScience
. 2024 Oct;
27(11):111104.
PMID: 39473976
Skeletal muscle cells (myofibers) are elongated non-mitotic, multinucleated syncytia that have adapted a microtubule lattice. Microtubule-associated proteins (MAPs) play roles in regulating microtubule architecture. The most abundant MAP in skeletal...
3.
Giudice J, Loehr J, Rodney G, Cooper T
Cell Rep
. 2016 Nov;
17(8):1923-1933.
PMID: 27851958
During development, transcriptional and post-transcriptional networks are coordinately regulated to drive organ maturation. Alternative splicing contributes by producing temporal-specific protein isoforms. We previously found that genes undergoing splicing transitions during...
4.
Loehr J, Stinnett G, Hernandez-Rivera M, Roten W, Wilson L, Pautler R, et al.
J Physiol
. 2016 Aug;
594(21):6395-6405.
PMID: 27555555
Key Points: Inhibiting Nox2 reactive oxygen species (ROS) production reduced in vivo calcium influx in dystrophic muscle. The lack of Nox2 ROS production protected against decreased in vivo muscle function...
5.
English K, Lee S, Loehr J, Ploutz-Snyder R, Ploutz-Snyder L
Aerosp Med Hum Perform
. 2015 Dec;
86(12 Suppl):A68-A77.
PMID: 26630197
Introduction: Long-duration spaceflight results in a loss of muscle strength that poses both operational and medical risks, particularly during emergency egress, upon return to Earth, and during future extraterrestrial exploration....
6.
Loehr J, Guilliams M, Petersen N, Hirsch N, Kawashima S, Ohshima H
Aerosp Med Hum Perform
. 2015 Dec;
86(12 Suppl):A14-A23.
PMID: 26630191
Physical training has been conducted on the International Space Station (ISS) for the past 10 yr as a countermeasure to physiological deconditioning during spaceflight. Each member space agency has developed...
7.
Loehr J, Abo-Zahrah R, Pal R, Rodney G
Front Physiol
. 2015 Feb;
5:530.
PMID: 25653619
Elevated concentrations of sphingomyelinase (SMase) have been detected in a variety of diseases. SMase has been shown to increase muscle derived oxidants and decrease skeletal muscle force; however, the sub-cellular...
8.
English K, Loehr J, Lee S, Smith S
Eur J Appl Physiol
. 2014 Jul;
114(11):2263-80.
PMID: 25048074
Purpose: Eccentric muscle actions are important to the development of muscle mass and strength and may affect bone mineral density (BMD). This study's purpose was to determine the relative effectiveness...
9.
Pal R, Palmieri M, Loehr J, Li S, Abo-Zahrah R, Monroe T, et al.
Nat Commun
. 2014 Jul;
5:4425.
PMID: 25028121
Duchenne muscular dystrophy (DMD) is a fatal degenerative muscle disease resulting from mutations in the dystrophin gene. Increased oxidative stress and altered Ca(2+) homeostasis are hallmarks of dystrophic muscle. While...
10.
Loehr J, Lee S, English K, Sibonga J, Smith S, Spiering B, et al.
Med Sci Sports Exerc
. 2010 May;
43(1):146-56.
PMID: 20473227
Unlabelled: Resistance exercise has been used as a means to prevent the musculoskeletal losses associated with spaceflight. Therefore, the National Aeronautics and Space Administration designed the Advanced Resistive Exercise Device...