Stuart M C Lee
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Explore the profile of Stuart M C Lee including associated specialties, affiliations and a list of published articles.
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66
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1551
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Recent Articles
1.
Honemann J, Hoffmann F, De Boni L, Gauger P, Mulder E, Mostl S, et al.
J Am Heart Assoc
. 2024 Oct;
13(21):e034800.
PMID: 39450723
Background: Orthostatic intolerance occurs following immobilization in patients on Earth and in astronauts after spaceflight. Head-down tilt bedrest is a terrestrial model for weightlessness and induces orthostatic intolerance. We hypothesized...
2.
Velichala S, Kassel R, Ly V, Watenpaugh D, Lee S, Macias B, et al.
Life (Basel)
. 2024 Jul;
14(7).
PMID: 39063548
Microgravity in spaceflight produces headward fluid shifts which probably contribute to Spaceflight-Associated Neuro-Ocular Syndrome (SANS). Developing new methods to mitigate these shifts is crucial for preventing SANS. One possible strategy...
3.
Morris P, Anderton R, Marshall-Goebel K, Britton J, Lee S, Smith N, et al.
Nat Rev Cardiol
. 2024 Jul;
21(10):667-681.
PMID: 39030270
For more than 60 years, humans have travelled into space. Until now, the majority of astronauts have been professional, government agency astronauts selected, in part, for their superlative physical fitness...
4.
Marshall-Goebel K, Lee S, Lytle J, Martin D, Miller C, Young M, et al.
J Appl Physiol (1985)
. 2024 Mar;
136(5):1105-1112.
PMID: 38482574
During spaceflight, fluids shift headward, causing internal jugular vein (IJV) distension and altered hemodynamics, including stasis and retrograde flow, that may increase the risk of thrombosis. This study's purpose was...
5.
Jasien J, Laurie S, Lee S, Martin D, Kemp D, Ebert D, et al.
J Appl Physiol (1985)
. 2022 Jul;
133(3):721-731.
PMID: 35861522
Weightlessness induces a cephalad shift of blood and cerebrospinal fluid that may increase intracranial pressure (ICP) during spaceflight, whereas lower body negative pressure (LBNP) may provide an opportunity to caudally...
6.
Charvat J, Leonard D, Barlow C, DeFina L, Willis B, Lee S, et al.
Mayo Clin Proc
. 2022 Jul;
97(7):1237-1246.
PMID: 35787853
Objective: To determine the long-term cardiovascular disease risk of astronauts with spaceflight exposure compared with a well-matched cohort. Methods: National Aeronautics and Space Administration (NASA) astronauts are selected into their...
7.
Sides M, Johnston 3rd S, Sirek A, Lee P, Blue R, Antonsen E, et al.
Aerosp Med Hum Perform
. 2021 Sep;
92(8):650-669.
PMID: 34503618
For over 50 yr, investigators have studied the physiological adaptations of the human system during short- and long-duration spaceflight exposures. Much of the knowledge gained in developing health countermeasures for...
8.
Laurie S, Greenwald S, Marshall-Goebel K, Pardon L, Gupta A, Lee S, et al.
Physiol Rep
. 2021 Aug;
9(15):e14977.
PMID: 34355874
Spaceflight associated neuro-ocular syndrome (SANS) is hypothesized to develop as a consequence of the chronic headward fluid shift that occurs in sustained weightlessness. We exposed healthy subjects (n = 24)...
9.
Greenwald S, Macias B, Lee S, Marshall-Goebel K, Ebert D, Liu J, et al.
J Appl Physiol (1985)
. 2021 Jun;
131(2):613-620.
PMID: 34166098
Spaceflight-associated neuro-ocular syndrome (SANS) develops during long-duration (>1 mo) spaceflight presumably because of chronic exposure to a headward fluid shift that occurs in weightlessness. We aimed to determine whether reversing...
10.
Marshall-Goebel K, Macias B, Kramer L, Hasan K, Ferguson C, Patel N, et al.
JAMA Ophthalmol
. 2021 May;
139(7):781-784.
PMID: 34014272
Importance: Long-duration spaceflight induces structural changes in the brain and eye. Identification of an association between cerebral and ocular changes could help determine if there are common or independent causes...