James A Hubert
Overview
Explore the profile of James A Hubert including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
568
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Recent Articles
1.
Lin H, Frassetto A, Kowalik Jr E, Nawrocki A, Lu M, Kosinski J, et al.
PLoS One
. 2012 Apr;
7(4):e35240.
PMID: 22506074
Short-chain fatty acids (SCFAs), primarily acetate, propionate, and butyrate, are metabolites formed by gut microbiota from complex dietary carbohydrates. Butyrate and acetate were reported to protect against diet-induced obesity without...
2.
Wang L, Hubert J, Lee S, Pan J, Qian S, Reitman M, et al.
Bioorg Med Chem Lett
. 2011 Apr;
21(10):2911-5.
PMID: 21493064
A series of six-membered heterocycle carboxamides were synthesized and evaluated as cholecystokinin 1 receptor (CCK1R) agonists. A pyrimidine core proved to be the best heterocycle, and SAR studies resulted in...
3.
Zhu C, Hansen A, Bateman T, Chen Z, Holt T, Hubert J, et al.
Bioorg Med Chem Lett
. 2008 Jul;
18(15):4393-6.
PMID: 18614364
High-throughput screening revealed diaryl pyrazole 3 as a selective albeit modest cholecystokinin 1 receptor (CCK1R) agonist. SAR studies led to the discovery and optimization of a novel class of 1,2-diaryl...