Drew T Weingarth
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Explore the profile of Drew T Weingarth including associated specialties, affiliations and a list of published articles.
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5
Citations
297
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Recent Articles
1.
Wang L, Hubert J, Lee S, Pan J, Qian S, Reitman M, et al.
Bioorg Med Chem Lett
. 2011 Apr;
21(10):2911-5.
PMID: 21493064
A series of six-membered heterocycle carboxamides were synthesized and evaluated as cholecystokinin 1 receptor (CCK1R) agonists. A pyrimidine core proved to be the best heterocycle, and SAR studies resulted in...
2.
Zhong H, Beaulaurier J, Lum P, Molony C, Yang X, MacNeil D, et al.
PLoS Genet
. 2010 May;
6(5):e1000932.
PMID: 20463879
Genome-wide association studies (GWAS) have demonstrated the ability to identify the strongest causal common variants in complex human diseases. However, to date, the massive data generated from GWAS have not...
3.
Berger R, Zhu C, Hansen A, Harper B, Chen Z, Holt T, et al.
Bioorg Med Chem Lett
. 2008 Aug;
18(17):4833-7.
PMID: 18684621
The discovery and structure-activity relationship of 1,2-diarylimidazole piperazine carboxamides bearing polar side chains as potent and selective cholecystokinin 1 receptor (CCK1R) agonists are described. Optimization of this series resulted in...
4.
Zhu C, Hansen A, Bateman T, Chen Z, Holt T, Hubert J, et al.
Bioorg Med Chem Lett
. 2008 Jul;
18(15):4393-6.
PMID: 18614364
High-throughput screening revealed diaryl pyrazole 3 as a selective albeit modest cholecystokinin 1 receptor (CCK1R) agonist. SAR studies led to the discovery and optimization of a novel class of 1,2-diaryl...
5.
Marsh D, Weingarth D, Novi D, Chen H, Trumbauer M, Chen A, et al.
Proc Natl Acad Sci U S A
. 2002 Feb;
99(5):3240-5.
PMID: 11867747
Melanin-concentrating hormone (MCH) is a cyclic 19-aa hypothalamic neuropeptide derived from a larger prohormone precursor of MCH (Pmch), which also encodes neuropeptide EI (NEI) and neuropeptide GE (NGE). Pmch-deficient (Pmch-/-)...