Jamal Bouitbir
Overview
Explore the profile of Jamal Bouitbir including associated specialties, affiliations and a list of published articles.
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Articles
72
Citations
1126
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Recent Articles
1.
Abegg V, Panajatovic M, Mancuso R, Allard J, Duthaler U, Odermatt A, et al.
Toxicol Lett
. 2024 Jan;
393:1-13.
PMID: 38219807
St. John's Wort preparations are used for the treatment of mild to moderate depression. They are usually well tolerated but can cause adverse reactions including liver toxicity in rare cases....
2.
Mancuso R, Schneider G, Hurzeler M, Gut M, Zurfluh J, Breitenstein W, et al.
Biochem Pharmacol
. 2023 Mar;
211:115504.
PMID: 36921634
Integrins are a family of cell surface receptors well-recognized for their therapeutic potential in a wide range of diseases. However, the development of integrin targeting medications has been impacted by...
3.
Pearson A, Haenni D, Bouitbir J, Hunt M, Payne B, Sachdeva A, et al.
Function (Oxf)
. 2023 Jan;
4(1):zqac065.
PMID: 36654930
Nephrotoxicity is a major cause of kidney disease and failure in drug development, but understanding of cellular mechanisms is limited, highlighting the need for better experimental models and methodological approaches....
4.
Novakova K, Torok M, Panajatovic M, Bouitbir J, Duong F, Handschin C, et al.
Int J Mol Sci
. 2022 Oct;
23(20).
PMID: 36293168
OCTN2 (SLC22A5) is a carnitine transporter whose main function is the active transport of carnitine into cells. In skeletal muscle and other organs, the regulation of the SLC22A5 gene transcription...
5.
Nsaibia M, Devendran A, Goubaa E, Bouitbir J, Capoulade R, Bouchareb R
J Clin Med
. 2022 Jun;
11(12).
PMID: 35743402
Calcific Aortic Valve Disease (CAVD) is a fibrocalcific disease. Lipoproteins and oxidized phospholipids play a substantial role in CAVD; the level of Lp(a) has been shown to accelerate the progression...
6.
Duthaler U, Bachmann F, Suenderhauf C, Grandinetti T, Pfefferkorn F, Haschke M, et al.
Clin Pharmacokinet
. 2022 May;
61(7):1039-1055.
PMID: 35570253
Background: Activities of hepatic cytochrome P450 enzymes (CYPs) are relevant for hepatic clearance of drugs and known to be decreased in patients with liver cirrhosis. Several studies have reported the...
7.
Bouitbir J, Panajatovic M, Krahenbuhl S
Int J Mol Sci
. 2022 Feb;
23(4).
PMID: 35216404
Tyrosine kinase inhibitors (TKIs) are associated with cardiac toxicity, which may be caused by mitochondrial toxicity. The underlying mechanisms are currently unclear and require further investigation. In the present study,...
8.
Roos N, Mancuso R, Sanvee G, Bouitbir J, Krahenbuhl S
Food Chem Toxicol
. 2022 Feb;
162:112869.
PMID: 35182693
The tyrosine kinase inhibitors (TKIs) imatinib and lapatinib are associated with severe hepatotoxicity, whose mechanisms are currently under investigation. As amphiphilic drugs, imatinib and lapatinib enrich in lysosomes. In the...
9.
Blaser L, Duthaler U, Bouitbir J, Leuppi-Taegtmeyer A, Liakoni E, Dolf R, et al.
Front Pharmacol
. 2021 Sep;
12:620635.
PMID: 34557087
The objective was to investigate the effect of metamizole on renal function in healthy, salt-depleted volunteers. In addition, the pharmacokinetics of the four major metamizole metabolites were assessed and correlated...
10.
Sanvee G, Hitzfeld L, Bouitbir J, Krahenbuhl S
Biochem Pharmacol
. 2021 Aug;
192:114750.
PMID: 34461118
Statins decrease the serum LDL-cholesterol concentration and reduce the risk for cardiovascular diseases but can cause myopathy, which may be related to mTORC inhibition. In the current study, we investigated...