Jakub Jonczyk
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Explore the profile of Jakub Jonczyk including associated specialties, affiliations and a list of published articles.
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40
Citations
360
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Recent Articles
1.
Mordyl B, Fajkis-Zajaczkowska N, Szafranska K, Siwek A, Gluch-Lutwin M, Zmudzki P, et al.
J Med Chem
. 2024 Dec;
67(24):21859-21889.
PMID: 39668673
Selective enhancement of synaptic GABA signaling mediated by GABA-A receptors has been previously reported to promote functional recovery after ischemic stroke, while tonic GABA signaling has been detrimental. To identify...
2.
Jonczyk J, Przybylska K, Staszewski M, Godyn J, Werner T, Stefaniak-Napieralska M, et al.
Molecules
. 2024 Nov;
29(22).
PMID: 39598660
Autism spectrum disorder is a complex neurodevelopmental disorder. The available medical treatment options for autism spectrum disorder are very limited. While the etiology and pathophysiology of autism spectrum disorder are...
3.
Panek D, Pasieka A, Jonczyk J, Gawlinska M, Zareba P, Siwek A, et al.
Angew Chem Int Ed Engl
. 2024 Nov;
64(6):e202420510.
PMID: 39523866
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and behavioral and psychological symptoms of dementia (BPSD). Given that cholinergic neurons are predominantly affected in AD, current treatments...
4.
Zagorska A, Czopek A, Fryc M, Jonczyk J
Biomolecules
. 2024 Jul;
14(7).
PMID: 39062511
The main protease (Mpro) of SARS-CoV-2 is an essential enzyme that plays a critical part in the virus's life cycle, making it a significant target for developing antiviral drugs. The...
5.
Marcinkowska M, Fajkis-Zajaczkowska N, Szafranska K, Jonczyk J, Siwek A, Mordyl B, et al.
ACS Chem Neurosci
. 2023 Feb;
14(6):1166-1180.
PMID: 36848624
Modulation of α1β2γ2GABA-A receptor subpopulation expressed in the basal ganglia region is a conceptually novel mode of pharmacological strategy that offers prospects to tackle a variety of neurological dysfunction. Although...
6.
Czarnecka K, Girek M, Krecisz P, Skibinski R, Latka K, Jonczyk J, et al.
J Enzyme Inhib Med Chem
. 2023 Jan;
38(1):2158822.
PMID: 36629422
Alzheimer's disease (AD) is a progressive neurodegenerative brain disease. Thus, drugs including donepezil, rivastigmine, and galantamine are not entirely effective in the treatment of this multifactorial disease. The present study...
7.
Kostrzewa T, Jonczyk J, Drzezdzon J, Jacewicz D, Gorska-Ponikowska M, Kolaczkowski M, et al.
Int J Mol Sci
. 2022 Jul;
23(13).
PMID: 35806035
One of the main goals of recent bioinorganic chemistry studies has been to design and synthesize novel substances to treat human diseases. The promising compounds are metal-based and metal ion...
8.
Staszewski M, Nelic D, Jonczyk J, Dubiel M, Frank A, Stark H, et al.
ACS Chem Neurosci
. 2021 Jun;
12(13):2503-2519.
PMID: 34100603
This article describes the discovery of novel potent muscarinic receptor antagonists identified during a search for more active histamine H receptor (HR) ligands. The idea was to replace the flexible...
9.
Pasieka A, Panek D, Jonczyk J, Godyn J, Szalaj N, Latacz G, et al.
Eur J Med Chem
. 2021 Apr;
218:113397.
PMID: 33838585
Looking for an effective anti-Alzheimer's agent is very challenging; however, a multifunctional ligand strategy may be a promising solution for the treatment of this complex disease. We herein present the...
10.
Jonczyk J, Kukulowicz J, Latka K, Malawska B, Jung Y, Musilek K, et al.
Biomolecules
. 2021 Jan;
11(2).
PMID: 33513955
Poisoning with organophosphorus compounds used as pesticides or misused as chemical weapons remains a serious threat to human health and life. Their toxic effects result from irreversible blockade of the...