Jae Kyo Yi
Overview
Explore the profile of Jae Kyo Yi including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
223
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0
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Recent Articles
1.
Sun Y, Patterson-Fortin J, Han S, Li Z, Nowicka Z, Hirohashi Y, et al.
Nat Commun
. 2024 Aug;
15(1):6676.
PMID: 39107288
53BP1 nucleates the anti-end resection machinery at DNA double-strand breaks, thereby countering BRCA1 activity. Loss of 53BP1 leads to DNA end processing and homologous recombination in BRCA1-deficient cells. Consequently, BRCA1-mutant...
2.
Yi J, Xu R, Obeid L, Hannun Y, Airola M, Mao C
PLoS One
. 2022 Sep;
17(9):e0271540.
PMID: 36048828
Human alkaline ceramidase 3 (ACER3) is one of three alkaline ceramidases (ACERs) that catalyze the conversion of ceramide to sphingosine. ACERs are members of the CREST superfamily of integral-membrane hydrolases....
3.
Yi J, Fujita H, Mandon E, Gilmore R
J Biol Chem
. 2021 Sep;
297(4):101171.
PMID: 34492269
The yeast endoplasmic reticulum has three distinct protein translocation channels. The heterotrimeric Sec61 and Ssh1 complexes, which bind translating ribosomes, mediate cotranslational translocation of proteins targeted to the endoplasmic reticulum...
4.
Wang K, Xu R, Schrandt J, Shah P, Gong Y, Preston C, et al.
PLoS Genet
. 2018 Jan;
14(1):e1007190.
PMID: 29360825
[This corrects the article DOI: 10.1371/journal.pgen.1005591.].
5.
Lin C, Xu R, Yi J, Li F, Chen J, Jones E, et al.
Stem Cell Reports
. 2017 Oct;
9(5):1488-1500.
PMID: 29056331
Ceramides and their metabolites are important for the homeostasis of the epidermis, but much remains unknown about the roles of specific pathways of ceramide metabolism in skin biology. With a...
6.
Chen J, Newcomb B, Zhou C, Pondick J, Ghoshal S, York S, et al.
Sci Rep
. 2017 Mar;
7:44867.
PMID: 28322247
Activation of hepatic stellate cells (HSCs) in response to injury is a key step in hepatic fibrosis, and is characterized by trans-differentiation of quiescent HSCs to HSC myofibroblasts, which secrete...
7.
Yi J, Xu R, Jeong E, Mileva I, Truman J, Lin C, et al.
Oncotarget
. 2016 Mar;
7(16):21124-44.
PMID: 27008706
Sphingoid bases (SBs) as bioactive sphingolipids, have been implicated in aging in yeast. However, we know neither how SBs are regulated during yeast aging nor how they, in turn, regulate...
8.
Edvardson S, Yi J, Jalas C, Xu R, Webb B, Snider J, et al.
J Med Genet
. 2016 Jan;
53(6):389-96.
PMID: 26792856
Background/aims: Leukodystrophies due to abnormal production of myelin cause extensive morbidity in early life; their genetic background is still largely unknown. We aimed at reaching a molecular diagnosis in Ashkenazi-Jewish...
9.
Wang K, Xu R, Schrandt J, Shah P, Gong Y, Preston C, et al.
PLoS Genet
. 2015 Oct;
11(10):e1005591.
PMID: 26474409
Dyshomeostasis of both ceramides and sphingosine-1-phosphate (S1P) in the brain has been implicated in aging-associated neurodegenerative disorders in humans. However, mechanisms that maintain the homeostasis of these bioactive sphingolipids in...
10.
Hernandez-Corbacho M, Canals D, Adada M, Liu M, Senkal C, Yi J, et al.
J Biol Chem
. 2015 Aug;
290(42):25356-73.
PMID: 26318452
Ceramide synthases (CerS1-CerS6), which catalyze the N-acylation of the (dihydro)sphingosine backbone to produce (dihydro)ceramide in both the de novo and the salvage or recycling pathway of ceramide generation, have been...