Jae-Hoon Ji
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Explore the profile of Jae-Hoon Ji including associated specialties, affiliations and a list of published articles.
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Articles
49
Citations
417
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Recent Articles
1.
Saladino N, Leavitt E, Wong H, Ji J, Ebrahimi D, Salamango D
bioRxiv
. 2025 Feb;
PMID: 39975144
Despite decades of research, the primary proviral function of the HIV-1 Vpr accessory protein remains enigmatic. Vpr is essential for pathogenesis and for virus replication in myeloid cells, but the...
2.
Salunkhe S, Daley J, Kaur H, Tomimatsu N, Xue C, Raina V, et al.
Nature
. 2024 Sep;
634(8033):482-491.
PMID: 39261729
The licensing step of DNA double-strand break repair by homologous recombination entails resection of DNA ends to generate a single-stranded DNA template for assembly of the repair machinery consisting of...
3.
Kim Y, Min S, Kim S, Lee S, Park Y, Heo Y, et al.
Nucleic Acids Res
. 2024 Sep;
52(19):11720-11737.
PMID: 39217466
PARP inhibitors (PARPi) show selective efficacy in tumors with homologous recombination repair (HRR)-defects but the activation mechanism of HRR pathway in PARPi-treated cells remains enigmatic. To unveil it, we searched...
4.
Huang Y, Li W, Foo T, Ji J, Wu B, Tomimatsu N, et al.
Nat Commun
. 2024 Aug;
15(1):7081.
PMID: 39152168
DSS1, essential for BRCA2-RAD51 dependent homologous recombination (HR), associates with the helical domain (HD) and OB fold 1 (OB1) of the BRCA2 DSS1/DNA-binding domain (DBD) which is frequently targeted by...
5.
Lee D, Kim I, Lee H, Seo M, Cho M, Lee H, et al.
Cell Death Dis
. 2024 Jan;
15(1):48.
PMID: 38218922
Valosin-containing protein (VCP)/p97, an AAA+ ATPase critical for maintaining proteostasis, emerges as a promising target for cancer therapy. This study reveals that targeting VCP selectively eliminates breast cancer cells while...
6.
Wang M, Li W, Tomimatsu N, Yu C, Ji J, Alejo S, et al.
Mol Cell
. 2023 Oct;
83(20):3679-3691.e8.
PMID: 37797621
The tumor-suppressor breast cancer 1 (BRCA1) in complex with BRCA1-associated really interesting new gene (RING) domain 1 (BARD1) is a RING-type ubiquitin E3 ligase that modifies nucleosomal histone and other...
7.
Min S, Ji J, Heo Y, Cho H
Exp Mol Med
. 2022 Oct;
54(10):1705-1712.
PMID: 36229590
In eukaryotic cells, DNA damage can occur at any time and at any chromatin locus, including loci at which active transcription is taking place. DNA double-strand breaks affect chromatin integrity...
8.
Ji J, Lee G, Koh J
Sci Rep
. 2022 Sep;
12(1):15583.
PMID: 36114221
In this study, piezoelectric composite nanofiber films were fabricated by introducing nitrogen-doped-reduced-graphene-oxide as a conductive material to a P(VDF-TrFE) polymer and a BiScO-PbTiO ceramic composite employing an electrospinning process. Nitrogen...
9.
Min S, Lee H, Ji J, Heo Y, Kim Y, Chae S, et al.
Nucleic Acids Res
. 2021 Dec;
49(21):12268-12283.
PMID: 34850117
DNA lesions impact on local transcription and the damage-induced transcriptional repression facilitates efficient DNA repair. However, how chromatin dynamics cooperates with these two events remained largely unknown. We here show...
10.
Kim J, Lee S, Hwang Y, Kim S, Chung J, Park S, et al.
Nucleic Acids Res
. 2021 Oct;
49(19):11083-11102.
PMID: 34614178
Mutual crosstalk among poly(ADP-ribose) (PAR), activated PAR polymerase 1 (PARP1) metabolites, and DNA repair machinery has emerged as a key regulatory mechanism of the DNA damage response (DDR). However, there...