Jacques J C Neefjes
Overview
Explore the profile of Jacques J C Neefjes including associated specialties, affiliations and a list of published articles.
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12
Citations
132
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Recent Articles
1.
van Gelder M, Li Y, Wander D, Berlin I, Overkleeft H, van der Zanden S, et al.
J Med Chem
. 2024 Aug;
67(16):13802-13812.
PMID: 39088428
Anthracyclines comprise one of the most effective anticancer drug classes. Doxorubicin, daunorubicin, epirubicin, and idarubicin have been in clinical use for decades, but their application remains complicated by treatment-related toxicities...
2.
Hulst M, Zhang L, van der Heul H, Du C, Elsayed S, Koroleva A, et al.
Front Bioeng Biotechnol
. 2024 Mar;
12:1363803.
PMID: 38481571
Daunorubicin and doxorubicin, two anthracycline polyketides produced by , are potent anticancer agents that are widely used in chemotherapy, despite severe side effects. Recent advances have highlighted the potential of...
3.
van Gelder M, van der Zanden S, Vriends M, Wagensveld R, van der Marel G, Codee J, et al.
J Med Chem
. 2023 Aug;
66(16):11390-11398.
PMID: 37561481
The anthracycline anti-cancer drugs are intensely used in the clinic to treat a wide variety of cancers. They generate DNA double strand breaks, but recently the induction of chromatin damage...
4.
Hulst M, Grocholski T, Neefjes J, van Wezel G, Metsa-Ketela M
Nat Prod Rep
. 2021 Dec;
39(4):814-841.
PMID: 34951423
Covering: January 1995 to June 2021Anthracyclines are glycosylated microbial natural products that harbour potent antiproliferative activities. Doxorubicin has been widely used as an anticancer agent in the clinic for several...
5.
Ciurli A, Liebl M, Derks R, Neefjes J, Giera M
iScience
. 2021 Jul;
24(7):102768.
PMID: 34278270
Saliva is a complex bodily fluid composed of metabolites secreted by major and minor glands, as well as by-products of host oral cells, oral bacteria, gingival crevicular fluid, and exogenous...
6.
Wander D, van der Zanden S, Vriends M, van Veen B, Vlaming J, Bruyning T, et al.
J Org Chem
. 2021 Mar;
86(8):5757-5770.
PMID: 33783212
Anthracyclines are effective drugs in the treatment of various cancers, but their use comes with severe side effects. The archetypal anthracycline drug, doxorubicin, displays two molecular modes of action: DNA...
7.
Duijster J, Hansen J, Franz E, Neefjes J, Frisch M, Mughini-Gras L, et al.
Epidemiol Infect
. 2021 Feb;
149:e56.
PMID: 33551005
Laboratory data increasingly suggest that Salmonella infection may contribute to colon cancer (CC) development. Here, we examined epidemiologically the potential risk of CC associated with salmonellosis in the human population....
8.
Van den Boomen D, Sienkiewicz A, Berlin I, Jongsma M, van Elsland D, Luzio J, et al.
Nat Commun
. 2020 Nov;
11(1):5559.
PMID: 33144569
Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and identify >100 genes involved in...
9.
Mankor J, Zwierenga F, Dumoulin D, Neefjes J, Aerts J
Eur J Cancer
. 2020 Aug;
137:40-44.
PMID: 32739768
Extensive-stage small-cell lung cancer (ES-SCLC) is an aggressive cancer that remains very hard to treat. The life expectancy of a patient diagnosed with this disease has not changed over the...
10.
Maurits E, van de Graaff M, Maiorana S, Wander D, Dekker P, van der Zanden S, et al.
J Am Chem Soc
. 2020 Apr;
142(16):7250-7253.
PMID: 32275401
Proteasome inhibitors are established therapeutic agents for the treatment of hematological cancers, as are anthracyclines such as doxorubicin. We here present a new drug targeting approach that combines both drug...