Jacob P Rose
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Explore the profile of Jacob P Rose including associated specialties, affiliations and a list of published articles.
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11
Citations
22
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Recent Articles
1.
Du H, Rose J, Bons J, Guo L, Valentino T, Wu F, et al.
Geroscience
. 2025 Jan;
PMID: 39826027
Cells are subjected to dynamic mechanical environments which impart forces and induce cellular responses. In age-related conditions like pulmonary fibrosis, there is both an increase in tissue stiffness and an...
2.
Zhang Y, Zhang B, Bharathi S, Bons J, Rose J, Shah S, et al.
Biomolecules
. 2025 Jan;
14(12.
PMID: 39766215
Lysine succinylation, and its reversal by sirtuin-5 (SIRT5), is known to modulate mitochondrial fatty acid β-oxidation (FAO). We recently showed that feeding mice dodecanedioic acid, a 12-carbon dicarboxylic acid (DC)...
3.
Du H, Rose J, Bons J, Guo L, Valentino T, Wu F, et al.
bioRxiv
. 2024 Nov;
PMID: 39605579
Cells are subjected to dynamic mechanical environments which impart forces and induce cellular responses. In age-related conditions like pulmonary fibrosis, there is both an increase in tissue stiffness and an...
4.
Schmidt A, Bharathi S, Solo K, Bons J, Rose J, Schilling B, et al.
Biomolecules
. 2024 Sep;
14(9).
PMID: 39334926
Sirtuin-2 (Sirt2), an NAD+-dependent lysine deacylase enzyme, has previously been implicated as a regulator of glucose metabolism, but the specific mechanisms remain poorly defined. Here, we observed that males, but...
5.
Liu H, Binoy A, Ren S, Martino T, Miller A, Willis C, et al.
bioRxiv
. 2024 Aug;
PMID: 39091806
Objectives: Chondrocyte metabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein post-translational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism....
6.
Patel S, Bons J, Rose J, Chappel J, Beres R, Watson M, et al.
bioRxiv
. 2024 Jul;
PMID: 38979258
Senescence emerged as a significant mechanism of aging and age-related diseases, offering an attractive target for clinical interventions. Senescent cells release a senescence-associated secretory phenotype (SASP), including exosomes that may...
7.
Zhang R, Bons J, Rose J, Schilling B, Verdin E
STAR Protoc
. 2024 May;
5(2):103074.
PMID: 38771695
Lysine malonylation is a protein posttranslational modification. We present a protocol to generate stable gene-knockdown K562 cell lines through lentiviral infection of a CRISPR interference (CRISPRi) system followed by lysine...
8.
Schurman C, Kaya S, Dole N, Luna N, Castillo N, Potter R, et al.
Bone Res
. 2024 Feb;
12(1):13.
PMID: 38409111
Poor bone quality is a major factor in skeletal fragility in elderly individuals. The molecular mechanisms that establish and maintain bone quality, independent of bone mass, are unknown but are...
9.
Silva Barbosa A, Pfister K, Chiba T, Bons J, Rose J, Burton J, et al.
J Am Soc Nephrol
. 2023 Dec;
35(2):135-148.
PMID: 38044490
Significance Statement: In this study, we demonstrate that a common, low-cost compound known as octanedioic acid (DC 8 ) can protect mice from kidney damage typically caused by ischemia-reperfusion injury...
10.
Dipali S, King C, Rose J, Burdette J, Campisi J, Schilling B, et al.
Aging (Albany NY)
. 2023 Oct;
15(20):10821-10855.
PMID: 37899138
The ovarian microenvironment becomes fibrotic and stiff with age, in part due to increased collagen and decreased hyaluronan. However, the extracellular matrix (ECM) is a complex network of hundreds of...