Jacob P Hoj
Overview
Explore the profile of Jacob P Hoj including associated specialties, affiliations and a list of published articles.
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11
Citations
85
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0
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Recent Articles
1.
Chaudhary P, Xu X, Wang G, Hoj J, Rampersad R, Asselin-Labat M, et al.
Cancer Res Commun
. 2023 Oct;
3(11):2400-2411.
PMID: 37882674
Significance: Identification of progenitor like tumor-initiating cells in KRAS-mutant lung adenocarcinoma may allow development of novel targeted therapeutics.
2.
Stanland L, Ang H, Hoj J, Chu Y, Tan P, Wood K, et al.
Mol Cancer Res
. 2023 Jul;
21(11):1148-1162.
PMID: 37493631
Implications: Loss of either NEDD9 or BCL-XL confers hypersensitivity to PI3K-alpha inhibition whereas loss of CBFB confers resistance through a CBFB/PIM1 signaling axis.
3.
Mayro B, Hoj J, Cerda-Smith C, Hutchinson H, Caminear M, Thrash H, et al.
Proc Natl Acad Sci U S A
. 2023 Apr;
120(16):e2210418120.
PMID: 37040401
The hypoxia-inducible factor 1-α (HIF-1α) enables cells to adapt and respond to hypoxia (Hx), and the activity of this transcription factor is regulated by several oncogenic signals and cellular stressors....
4.
Killarney S, Washart R, Soderquist R, Hoj J, Lebhar J, Lin K, et al.
Nat Commun
. 2023 Mar;
14(1):1399.
PMID: 36918588
During apoptosis, mitochondrial outer membrane permeabilization (MOMP) enables certain mitochondrial matrix macromolecules to escape into the cytosol. However, the fate of mitochondrial RNA (mtRNA) during apoptosis is unknown. Here, we...
5.
Bassil C, Anderson G, Mayro B, Askin K, Winter P, Gruber S, et al.
bioRxiv
. 2023 Jan;
PMID: 36711936
Targeted therapies have revolutionized cancer chemotherapy. Unfortunately, most patients develop multifocal resistance to these drugs within a matter of months. Here, we used a high-throughput phenotypic small molecule screen to...
6.
Luttman J, Hoj J, Lin K, Lin J, Gu J, Rouse C, et al.
Cell Rep
. 2021 Oct;
37(4):109880.
PMID: 34706244
Targeting mitochondrial metabolism has emerged as a treatment option for cancer patients. The ABL tyrosine kinases promote metastasis, and enhanced ABL signaling is associated with a poor prognosis in lung...
7.
Hoj J, Mayro B, Pendergast A
Proc Natl Acad Sci U S A
. 2020 Dec;
117(52):33486-33495.
PMID: 33318173
Brain metastases are the most common intracranial tumors in adults and are associated with increased patient morbidity and mortality. Limited therapeutic options are currently available for the treatment of brain...
8.
Hoj J, Mayro B, Pendergast A
Cell Rep
. 2019 Dec;
29(11):3421-3434.e8.
PMID: 31825826
Brain metastases are a common consequence of advanced lung cancer, resulting in cranial neuropathies and increased mortality. Currently, there are no effective therapies to treat brain metastases due to a...
9.
Siddiqui-Jain A, Hoj J, Cescon D, Hansen M
Bioorg Med Chem Lett
. 2018 Feb;
28(5):934-941.
PMID: 29433928
Microtubule-targeting agents are important tools in cancer treatment. Generating novel microtubule targeting agents with novel pharmacology could dramatically expand the utility of this class of drugs. Here we characterize the...
10.
Pyridine-pyrimidine amides that prevent HGF-induced epithelial scattering by two distinct mechanisms
Siddiqui-Jain A, Hoj J, Hargiss J, Hoj T, Payne C, Ritchie C, et al.
Bioorg Med Chem Lett
. 2017 Aug;
27(17):3992-4000.
PMID: 28780159
Stimulation of cultured epithelial cells with scatter factor/hepatocyte growth factor (HGF) results in individual cells detaching and assuming a migratory and invasive phenotype. Epithelial scattering recapitulates cancer progression and studies...