Jacob N Finkelstein
Overview
Explore the profile of Jacob N Finkelstein including associated specialties, affiliations and a list of published articles.
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59
Citations
1441
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Recent Articles
1.
Beach T, Finkelstein J, Chang P
Radiat Res
. 2023 May;
199(5):439-451.
PMID: 37237442
Radiation models, such as whole thorax lung irradiation (WTLI) or partial-body irradiation (PBI) with bone-marrow sparing, have shown that affected lung tissue displays a continual progression of injury, often for...
2.
Beach T, Finkelstein J, Chang P
Radiat Res
. 2023 Mar;
PMID: 36928358
Radiation models, such as whole thorax lung irradiation (WTLI) or partial-body irradiation (PBI) with bone-marrow sparing, have shown that affected lung tissue displays a continual progression of injury, often for...
3.
Wang J, Kim S, House E, Olson H, Johnston C, Chalupa D, et al.
Arch Toxicol
. 2021 May;
95(7):2469-2483.
PMID: 34031698
Bronchiolitis obliterans (BO) is a devastating lung disease seen commonly after lung transplant, following severe respiratory tract infection or chemical inhalation exposure. Diacetyl (DA; 2,3-butanedione) is a highly reactive alpha-diketone...
4.
McGraw M, Kim S, Reed C, Hernady E, Rahman I, Mariani T, et al.
Toxicol Lett
. 2020 Mar;
325:25-33.
PMID: 32112875
Rationale: Diacetyl (DA; 2,3-butanedione) is a chemical found commonly in foods and e-cigarettes. When inhaled, DA causes epithelial injury, though the mechanism of repair remain poorly understood. The objective of...
5.
Hanson K, Hernady E, Reed C, Johnston C, Groves A, Finkelstein J
Toxicol Sci
. 2019 Apr;
170(2):489-498.
PMID: 31020321
Inhalation of environmental toxicants such as cigarette smoke, metal or wood dust, silica, or asbestos is associated with increased risk for idiopathic pulmonary fibrosis (IPF). IPF involves progressive scarring of...
6.
Hanson K, Finkelstein J
Anal Biochem
. 2018 Oct;
564-565:96-101.
PMID: 30365977
We present a real-time, high-throughput, and cost-effective method of detecting apoptosis in vitro using a previously developed reagent that detects caspase activation by fluorescence. Current methods of assessing apoptosis fail...
7.
Beach T, Groves A, Williams J, Finkelstein J
Int J Radiat Biol
. 2018 Oct;
96(1):129-144.
PMID: 30359147
Models of thoracic irradiation have been developed as clinicians and scientists have attempted to decipher the events that led up to the pulmonary toxicity seen in human subjects following radiation...
8.
Beach T, Groves A, Johnston C, Williams J, Finkelstein J
Int J Radiat Biol
. 2018 Sep;
94(12):1104-1115.
PMID: 30238842
Purpose: Radiation-induced lung injuries (RILI), namely radiation pneumonitis and/or fibrosis, are dose-limiting outcomes following treatment for thoracic cancers. As part of a search for mitigation targets, we sought to determine...
9.
Groves A, Williams J, Hernady E, Reed C, Fenton B, Love T, et al.
Radiat Res
. 2018 Aug;
190(5):513-525.
PMID: 30117783
Biomarkers could play an essential role during triage in the aftermath of a radiological event, where exposure to radiation will be heterogeneous and complicated by concurrent trauma. Used alongside biodosimetry,...
10.
Groves A, Johnston C, Williams J, Finkelstein J
Radiat Res
. 2018 Jan;
189(3):300-311.
PMID: 29332538
Lung exposure to radiation induces an injury response that includes the release of cytokines and chemotactic mediators; these signals recruit immune cells to execute inflammatory and wound-healing processes. However, radiation...