Jacob Holechek
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Explore the profile of Jacob Holechek including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
34
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Recent Articles
1.
Sturniolo I, Varoczy C, Regdon Z, Mazlo A, Muzsai S, Bacsi A, et al.
Int J Mol Sci
. 2024 Apr;
25(7).
PMID: 38612413
Cancers reprogram macrophages (MΦs) to a tumor-growth-promoting TAM (tumor-associated MΦ) phenotype that is similar to the anti-inflammatory M2 phenotype. Poly(ADP-ribose) polymerase (PARP) enzymes regulate various aspects of MΦ biology, but...
2.
Holechek J, Lease R, Thorsell A, Karlberg T, McCadden C, Grant R, et al.
Bioorg Med Chem Lett
. 2018 May;
28(11):2050-2054.
PMID: 29748053
A series of diaryl ethers were designed and synthesized to discern the structure activity relationships against the two closely related mono-(ADP-ribosyl)transferases PARP10 and PARP14. Structure activity studies identified 8b as...
3.
Upton K, Meyers M, Thorsell A, Karlberg T, Holechek J, Lease R, et al.
Bioorg Med Chem Lett
. 2017 May;
27(13):2907-2911.
PMID: 28495083
A series of (Z)-4-(3-carbamoylphenylamino)-4-oxobut-2-enyl amides were synthesized and tested for their ability to inhibit the mono-(ADP-ribosyl)transferase, PARP14 (a.k.a. BAL-2; ARTD-8). Two synthetic routes were established for this series and several...