Jacob F Jeppesen
Overview
Explore the profile of Jacob F Jeppesen including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
423
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0
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Recent Articles
1.
Moller L, Ali M, Davey J, Raun S, Andersen N, Long J, et al.
Proc Natl Acad Sci U S A
. 2023 Jun;
120(27):e2211041120.
PMID: 37364105
The molecular events governing skeletal muscle glucose uptake have pharmacological potential for managing insulin resistance in conditions such as obesity, diabetes, and cancer. With no current pharmacological treatments to target...
2.
DallAgnese A, Platt J, Zheng M, Friesen M, DallAgnese G, Blaise A, et al.
Nat Commun
. 2022 Dec;
13(1):7522.
PMID: 36473871
Insulin receptor (IR) signaling is central to normal metabolic control and is dysregulated in metabolic diseases such as type 2 diabetes. We report here that IR is incorporated into dynamic...
3.
Ma H, Zwaan E, Guo Y, Cejas P, Thiru P, van de Bunt M, et al.
Cell Stem Cell
. 2022 Nov;
29(11):1611.
PMID: 36332573
No abstract available.
4.
Madsen C, Refsgaard J, Teufel F, Kjaerulff S, Wang Z, Meng G, et al.
Nat Commun
. 2022 Oct;
13(1):6235.
PMID: 36266275
Peptides play important roles in regulating biological processes and form the basis of a multiplicity of therapeutic drugs. To date, only about 300 peptides in human have confirmed bioactivity, although...
5.
Friesen M, Khalil A, Barrasa M, Jeppesen J, Mooney D, Jaenisch R
Sci Adv
. 2022 Jun;
8(24):eabn7298.
PMID: 35714187
Adipocytes are key regulators of human metabolism, and their dysfunction in insulin signaling is central to metabolic diseases including type II diabetes mellitus (T2D). However, the progression of insulin resistance...
6.
Ma H, Zwaan E, Guo Y, Cejas P, Thiru P, van de Bunt M, et al.
Cell Stem Cell
. 2022 Apr;
29(5):795-809.e11.
PMID: 35452598
To understand the mechanisms regulating the in vitro maturation of hPSC-derived hepatocytes, we developed a 3D differentiation system and compared gene regulatory elements in human primary hepatocytes with those in...
7.
Ma H, Jeppesen J, Jaenisch R
Cell Rep Med
. 2020 Nov;
1(6):100097.
PMID: 33205073
Autoimmune destruction of pancreatic β cells underlies type 1 diabetes (T1D). To understand T cell-mediated immune effects on human pancreatic β cells, we combine β cell-specific expression of a model...
8.
Reddy A, Bozi L, Yaghi O, Mills E, Xiao H, Nicholson H, et al.
Cell
. 2020 Sep;
183(1):62-75.e17.
PMID: 32946811
In response to skeletal muscle contraction during exercise, paracrine factors coordinate tissue remodeling, which underlies this healthy adaptation. Here we describe a pH-sensing metabolite signal that initiates muscle remodeling upon...
9.
Fritzen A, Domingo-Espin J, Lundsgaard A, Kleinert M, Israelsen I, Carl C, et al.
Mol Metab
. 2020 Apr;
35:100949.
PMID: 32244181
Objective: Acute administration of the main protein component of high-density lipoprotein, apolipoprotein A-I (ApoA-1), improves glucose uptake in skeletal muscle. The molecular mechanisms mediating this are not known, but in...
10.
Gabery S, Salinas C, Paulsen S, Ahnfelt-Ronne J, Alanentalo T, Baquero A, et al.
JCI Insight
. 2020 Mar;
5(6).
PMID: 32213703
Semaglutide, a glucagon-like peptide 1 (GLP-1) analog, induces weight loss, lowers glucose levels, and reduces cardiovascular risk in patients with diabetes. Mechanistic preclinical studies suggest weight loss is mediated through...