Jacob D McDonald
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Explore the profile of Jacob D McDonald including associated specialties, affiliations and a list of published articles.
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121
Citations
1841
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Recent Articles
1.
Vermillion M, Saari N, Bray M, Nelson A, Bullard R, Rudolph K, et al.
Int J Mol Sci
. 2024 Apr;
25(7).
PMID: 38612759
As a regulator of alveolo-capillary barrier integrity, Transient Receptor Potential Vanilloid 4 (TRPV4) antagonism represents a promising strategy for reducing pulmonary edema secondary to chemical inhalation. In an experimental model...
2.
Ruzycki C, Montoya D, Irshad H, Cox J, Zhou Y, McDonald J, et al.
Expert Opin Drug Deliv
. 2023 Sep;
20(8):1097-1113.
PMID: 37732957
Introduction: Inhaled gene therapy programs targeting diseases of the lung have seen increasing interest in recent years, though as of yet no product has successfully entered the market. Preclinical research...
3.
Jenkins B, Moore C, Covey D, McDonald J, Lefever T, Bonn-Miller M, et al.
Cannabis Cannabinoid Res
. 2023 Sep;
8(S1):S11-S24.
PMID: 37721993
Cannabis and its primary psychoactive constituent delta-9-tetrahydrocannabinol (D9-THC) produce biphasic, dose-dependent effects on anxiety. In addition to D9-THC, cannabis contains other "minor" cannabinoids and terpenes with purported therapeutic potential for...
4.
Moore C, Weerts E, Kulpa J, Schwotzer D, Dye W, Jantzi J, et al.
Cannabis Cannabinoid Res
. 2023 Sep;
8(S1):S51-S61.
PMID: 37721988
Minor cannabinoids are increasingly being consumed in oral formulations (i.e., edibles, tinctures) for medical and nonmedical purposes. This study examined the pharmacokinetics (PKs) of cannabinoids tetrahydrocannabivarin (THCV), cannabichromene (CBC), cannabinol...
5.
Lichtiger L, Jezioro J, Rivera J, McDonald J, Terry M, Sahay D, et al.
Environ Res
. 2023 May;
231(Pt 2):116213.
PMID: 37224940
Environmental exposure to polycyclic aromatic hydrocarbons (PAH) has been shown to be associated with chronic disease outcomes through multiple mechanisms including altered regulation of the transcription factor peroxisome proliferator-activated receptor...
6.
Kuehl P, Corr S, Farrar J, McDonald J, Wermer T, Weber D, et al.
J Pharmacol Toxicol Methods
. 2023 May;
122:107271.
PMID: 37196729
Introduction: 1,1-Difluoroethane (HFA-152a) is being developed as an alternative propellant in pressurized metered dose inhalers (pMDIs). As a part of the regulatory development pathway, pharmacology, toxicology and clinical studies have...
7.
Irshad H, Kulpa J, Kuehl P, Lefever T, McDonald J
Inhal Toxicol
. 2023 May;
35(5-6):169-174.
PMID: 37159420
Objective: Availability and consumer use of hemp products is rapidly increasing, but little work has been done to assess aerosol emissions of hemp pre-rolls. The objective of this research was...
8.
Kuehl P, McDonald J, Weber D, Khlystov A, Nystoriak M, Conklin D
Inhal Toxicol
. 2022 Aug;
34(11-12):319-328.
PMID: 35913821
The cardiovascular toxicity of unheated and heated flavorants and their products as commonly present in electronic cigarette liquids (e-liquids) was evaluated previously . Based on the results of assays, cinnamaldehyde,...
9.
Adivi A, Lucero J, Simpson N, McDonald J, Lund A
Neurotoxicol Teratol
. 2022 Jan;
90:107071.
PMID: 35016995
Epidemiology studies suggest that exposure to ambient air pollution is associated with demyelinating diseases in the central nervous system (CNS), including multiple sclerosis (MS). The pathophysiology of MS results from...
10.
Watson A, Moeller B, Doyle-Eisele M, Garner E, Blystone C, McDonald J, et al.
Xenobiotica
. 2021 Mar;
51(6):689-702.
PMID: 33683982
Ethylene glycol 2-ethylhexyl ether (EGEHE) is a solvent used in a variety of applications.We report disposition and metabolism of EGEHE following a single gavage or dermal administration of 50, 150...