Jacob Cobb
Overview
Explore the profile of Jacob Cobb including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
25
Followers
0
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Recent Articles
1.
Cobb J, Rawson J, Gonzalez N, Orr C, Kandeel F, Husseiny M
PLoS One
. 2024 May;
19(5):e0303863.
PMID: 38781241
Type 1 diabetes (T1D)-associated hyperglycemia develops, in part, from loss of insulin-secreting beta cells. The degree of glycemic dysregulation and the age at onset of disease can serve as indicators...
2.
Cobb J, Rawson J, Gonzalez N, Singer M, Kandeel F, Husseiny M
Vaccines (Basel)
. 2024 Mar;
12(3).
PMID: 38543910
A combination therapy of preproinsulin (PPI) and immunomodulators (TGFβ+IL10) orally delivered via genetically modified and anti-CD3 promoted glucose balance in in NOD mice with recent onset diabetes. The bacteria were...
3.
Cobb J, Soliman S, Retuerto M, Quijano J, Orr C, Ghannoum M, et al.
PLoS One
. 2023 May;
18(5):e0285905.
PMID: 37224176
We developed an oral Salmonella-based vaccine that prevents and reverses diabetes in non-obese diabetic (NOD) mice. Related to this, the gastrointestinal tract harbors a complex dynamic population of microorganisms, the...
4.
Cobb J, Rawson J, Gonzalez N, Hensel M, Kandeel F, Husseiny M
Front Immunol
. 2021 Jun;
12:667897.
PMID: 34108968
A therapy that includes an oral vaccine for type 1 diabetes (T1D) using live attenuated MvP728 (ΔΔ), cytokines (IL10 and TGFβ) and preproinsulin (PPI) antigen in combination with a sub-therapeutic...
5.
Mbongue J, Rawson J, Garcia P, Gonzalez N, Cobb J, Kandeel F, et al.
Front Immunol
. 2019 Mar;
10:320.
PMID: 30863412
Autoimmune diseases such as type 1 diabetes (T1D) involve the loss of regulatory mechanisms resulting in increased tissue-specific cytotoxicity. The result is destruction of pancreatic insulin-producing β-cells and loss of...