Jacob Amersfoort
Overview
Explore the profile of Jacob Amersfoort including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
325
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0
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Recent Articles
1.
Schaftenaar F, van Dam A, de Bruin G, Depuydt M, de Mol J, Amersfoort J, et al.
Arterioscler Thromb Vasc Biol
. 2024 Apr;
44(6):1346-1364.
PMID: 38660806
Background: Atherosclerosis is the major underlying pathology of cardiovascular disease and is driven by dyslipidemia and inflammation. Inhibition of the immunoproteasome, a proteasome variant that is predominantly expressed by immune...
2.
Geldhof V, de Rooij L, Sokol L, Amersfoort J, De Schepper M, Rohlenova K, et al.
Nat Commun
. 2022 Sep;
13(1):5511.
PMID: 36127427
Since a detailed inventory of endothelial cell (EC) heterogeneity in breast cancer (BC) is lacking, here we perform single cell RNA-sequencing of 26,515 cells (including 8433 ECs) from 9 BC...
3.
de Rooij L, Becker L, Teuwen L, Boeckx B, Jansen S, Feys S, et al.
Cardiovasc Res
. 2022 Aug;
119(2):520-535.
PMID: 35998078
Aims: Severe acute respiratory syndrome coronavirus-2 infection causes COVID-19, which in severe cases evokes life-threatening acute respiratory distress syndrome (ARDS). Transcriptome signatures and the functional relevance of non-vascular cell types...
4.
Amersfoort J, Eelen G, Carmeliet P
Nat Rev Immunol
. 2022 Mar;
22(9):576-588.
PMID: 35288707
Blood vessel endothelial cells (ECs) have long been known to modulate inflammation by regulating immune cell trafficking, activation status and function. However, whether the heterogeneous EC populations in various tissues...
5.
Douna H, De Mol J, Amersfoort J, Schaftenaar F, Kiss M, Suur B, et al.
Front Cardiovasc Med
. 2022 Feb;
9:781436.
PMID: 35187121
B and T cells are interconnected in the T follicular helper-germinal center B cell (T-GC B cell) axis, which is hyperactive during atherosclerosis development and loss of control along this...
6.
Teuwen L, de Rooij L, Cuypers A, Rohlenova K, Dumas S, Garcia-Caballero M, et al.
Cell Rep
. 2021 Jun;
35(11):109253.
PMID: 34133923
Tumor vessel co-option is poorly understood, yet it is a resistance mechanism against anti-angiogenic therapy (AAT). The heterogeneity of co-opted endothelial cells (ECs) and pericytes, co-opting cancer and myeloid cells...
7.
Amersfoort J, Schaftenaar F, Douna H, van Santbrink P, van Puijvelde G, Slutter B, et al.
Cardiovasc Res
. 2020 Jul;
117(5):1309-1324.
PMID: 32653923
Aims: A hallmark of advanced atherosclerosis is inadequate immunosuppression by regulatory T (Treg) cells inside atherosclerotic lesions. Dyslipidemia has been suggested to alter Treg cell migration by affecting the expression...
8.
Schaftenaar F, Amersfoort J, Douna H, Kroner M, Foks A, Bot I, et al.
Sci Rep
. 2019 Nov;
9(1):17391.
PMID: 31757993
Cardiovascular diseases form the most common cause of death worldwide, with atherosclerosis as main etiology. Atherosclerosis is marked by cholesterol rich lipoprotein deposition in the artery wall, evoking a pathogenic...
9.
Douna H, Amersfoort J, Schaftenaar F, Kroner M, Kiss M, Slutter B, et al.
Cardiovasc Res
. 2019 Jun;
116(2):295-305.
PMID: 31150053
Aims: The immune system is strongly involved in atherosclerosis and immune regulation generally leads to attenuated atherosclerosis. B- and T-lymphocyte attenuator (BTLA) is a novel co-receptor that negatively regulates the...
10.
Amersfoort J, Douna H, Schaftenaar F, Foks A, Kroner M, van Santbrink P, et al.
Front Immunol
. 2019 Jan;
9:2937.
PMID: 30619297
Macroautophagy (or autophagy) is a conserved cellular process in which cytoplasmic cargo is targeted for lysosomal degradation. Autophagy is crucial for the functional integrity of different subsets of T cells...