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Jack Rubinstein

Explore the profile of Jack Rubinstein including associated specialties, affiliations and a list of published articles. Areas
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Articles 84
Citations 878
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Recent Articles
1.
Rubinstein J, Pinney S, Xie C, Wang H
Environ Health . 2024 Sep; 23(1):76. PMID: 39300535
Background: Exposure to phenols has been linked in animal models and human populations to cardiac function alterations and cardiovascular diseases, although their effects on cardiac electrical properties in humans remains...
2.
Desai D, Baby A, Ananthamohan K, Green L, Arif M, Duncan B, et al.
J Mol Cell Cardiol Plus . 2024 Jul; 8. PMID: 38957358
Type 2 diabetes mellitus (T2DM) is a metabolic disease and comorbidity associated with several conditions, including cardiac dysfunction leading to heart failure with preserved ejection fraction (HFpEF), in turn resulting...
3.
Rubinstein J, Pinney S, Xie C, Wang H
Res Sq . 2024 Jun; PMID: 38853936
Background: Exposure to phenols has been linked in animal models and human populations to cardiac function alterations and cardiovascular diseases, although their effects on cardiac electrical properties in humans remains...
4.
McNamara J, Song T, Alam P, Binek A, Singh R, Nieman M, et al.
bioRxiv . 2024 May; PMID: 38746225
Significance Statement: Recently, the sarcomere - the machinery that controls heart and muscle contraction - has emerged as a central target for development of cardiac therapeutics. However, there remains much...
5.
Shah S, Christianson A, Meganathan K, Leonard A, Crews D, Rubinstein J, et al.
J Am Heart Assoc . 2024 May; 13(9):e029691. PMID: 38700013
Background: Cardiovascular disease is the leading cause of mortality in patients with kidney failure, and their risk of cardiovascular events is 10 to 20 times higher as compared with the...
6.
Haworth K, Niederhausen K, Smith E, Sadayappan S, Wess Y, Rubinstein J, et al.
Acad Med . 2023 May; 98(10):1120-1130. PMID: 37200479
A combination of forces have markedly increased challenges to research-active faculty achieving sustained success. This article describes how one department at the University of Cincinnati College of Medicine (UCCOM) implemented...
7.
Joseph J, Pajewski N, Dolor R, Sellers M, Perdue L, Peeples S, et al.
J Am Geriatr Soc . 2023 Apr; 71(6):1701-1713. PMID: 37082807
Whether initiation of statins could increase survival free of dementia and disability in adults aged ≥75 years is unknown. PREVENTABLE, a double-blind, placebo-controlled randomized pragmatic clinical trial, will compare high-intensity...
8.
Kumar M, Haghighi K, Koch S, Rubinstein J, Stillitano F, Hajjar R, et al.
Int J Mol Sci . 2023 Feb; 24(3). PMID: 36768995
Phospholamban () is a major regulator of cardiac contractility, and human mutations in this gene give rise to inherited cardiomyopathies. The deletion of Arginine 14 is the most-prevalent cardiomyopathy-related mutation,...
9.
Koch S, Martin E, Verma A, Adjei S, Rubinstein J
PLoS One . 2023 Jan; 18(1):e0280216. PMID: 36652449
Short bouts of occlusion of blood flow can induce a preconditioning response that reduces subsequent damage from longer periods of ischemia. It has been shown that ischemic preconditioning (IPC) can...
10.
Koch S, Marckel J, Rubinstein J, Norman A
Pharmacol Res Perspect . 2023 Jan; 11(1):e01045. PMID: 36631960
The recombinant monoclonal anti-cocaine antibody, h2E2, sequesters cocaine in plasma increasing concentrations more than 10-fold. The increased levels of cocaine in the plasma could have detrimental peripheral effects, particularly on...