Jack R Bennink
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Explore the profile of Jack R Bennink including associated specialties, affiliations and a list of published articles.
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81
Citations
4169
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Recent Articles
11.
Hickman H, Reynoso G, Ngudiankama B, Cush S, Gibbs J, Bennink J, et al.
Immunity
. 2015 Mar;
42(3):524-37.
PMID: 25769612
CD8(+) T cells play a critical role in limiting peripheral virus replication, yet how they locate virus-infected cells within tissues is unknown. Here, we have examined the environmental signals that...
12.
Brooke C, Ince W, Wei J, Bennink J, Yewdell J
Proc Natl Acad Sci U S A
. 2014 Nov;
111(47):16854-9.
PMID: 25385602
The influenza A virus (IAV) genome is divided into eight distinct RNA segments believed to be copackaged into virions with nearly perfect efficiency. Here, we describe a mutation in IAV...
13.
Magadan J, Altman M, Ince W, Hickman H, Stevens J, Chevalier A, et al.
PLoS Pathog
. 2014 Jun;
10(6):e1004204.
PMID: 24945804
Antigenic variation in the globular domain of influenza A virus (IAV) hemagglutinin (HA) precludes effective immunity to this major human pathogen. Although the HA stem is highly conserved between influenza...
14.
Bennink J
Monoclon Antib Immunodiagn Immunother
. 2014 Jun;
33(3):199.
PMID: 24893278
No abstract available.
15.
Magadan J, Khurana S, Das S, Frank G, Stevens J, Golding H, et al.
J Virol
. 2013 Jul;
87(17):9742-53.
PMID: 23824811
Influenza A virus (IAV) remains an important human pathogen largely because of antigenic drift, the rapid emergence of antibody escape mutants that precludes durable vaccination. The most potent neutralizing antibodies...
16.
Gilchuk P, Spencer C, Conant S, Hill T, Gray J, Niu X, et al.
J Clin Invest
. 2013 Apr;
123(5):1976-87.
PMID: 23543059
CD8+ T cells (TCD8) confer protective immunity against many infectious diseases, suggesting that microbial TCD8 determinants are promising vaccine targets. Nevertheless, current T cell antigen identification approaches do not discern...
17.
Defining influenza A virus hemagglutinin antigenic drift by sequential monoclonal antibody selection
Das S, Hensley S, Ince W, Brooke C, Subba A, Delboy M, et al.
Cell Host Microbe
. 2013 Mar;
13(3):314-23.
PMID: 23498956
Human influenza A virus (IAV) vaccination is limited by "antigenic drift," rapid antibody-driven escape reflecting amino acid substitutions in the globular domain of hemagglutinin (HA), the viral attachment protein. To...
18.
Hickman H, Reynoso G, Ngudiankama B, Rubin E, Magadan J, Cush S, et al.
Cell Host Microbe
. 2013 Feb;
13(2):155-68.
PMID: 23414756
Despite extensive ex vivo investigation, the spatiotemporal organization of immune cells interacting with virus-infected cells in tissues remains uncertain. To address this, we used intravital multiphoton microscopy to visualize immune...
19.
Ince W, Gueye-Mbaye A, Bennink J, Yewdell J
J Virol
. 2013 Feb;
87(8):4330-8.
PMID: 23365443
Influenza A virus (IAV) infects a remarkably wide variety of avian and mammalian hosts. Evolution finely hones IAV genes to optimally infect and be transmitted in a particular host species....
20.
Brooke C, Ince W, Wrammert J, Ahmed R, Wilson P, Bennink J, et al.
J Virol
. 2013 Jan;
87(6):3155-62.
PMID: 23283949
Segmentation of the influenza A virus (IAV) genome enables rapid gene reassortment at the cost of complicating the task of assembling the full viral genome. By simultaneously probing for the...