Jacek Mokrosinski
Overview
Explore the profile of Jacek Mokrosinski including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
778
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0
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Recent Articles
1.
Kizilkaya H, Sorensen K, Madsen J, Lindquist P, Douros J, Bork-Jensen J, et al.
Nat Metab
. 2024 Jun;
6(7):1268-1281.
PMID: 38871982
Incretin-based therapies are highly successful in combatting obesity and type 2 diabetes. Yet both activation and inhibition of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) in combination with glucagon-like peptide-1...
2.
Douros J, Mokrosinski J, Finan B
J Endocrinol
. 2024 Mar;
261(2).
PMID: 38451873
The glucagon-like peptide 1 receptor (GLP-1R) is a class B G protein-coupled receptor (GPCR) that emerged as a pharmacologic target in cardiometabolic disease, including diabetes and obesity, over 30 years...
3.
Dittmann M, Lakatos G, Wainwright J, Mokrosinski J, Cross E, Farooqi I, et al.
Sci Adv
. 2024 Mar;
10(10):eadj3823.
PMID: 38446876
Mutations that perturb leptin-melanocortin signaling are known to cause hyperphagia and obesity, but energy expenditure has not been well studied outside rodents. We report on a common canine mutation in...
4.
Talbot F, Feetham C, Mokrosinski J, Lawler K, Keogh J, Henning E, et al.
Nat Commun
. 2023 Mar;
14(1):1450.
PMID: 36922513
Disruption of brain-expressed G protein-coupled receptor-10 (GPR10) causes obesity in animals. Here, we identify multiple rare variants in GPR10 in people with severe obesity and in normal weight controls. These...
5.
He Y, Brouwers B, Liu H, Liu H, Lawler K, Mendes de Oliveira E, et al.
Nat Med
. 2022 Dec;
28(12):2537-2546.
PMID: 36536256
Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and depression. Here we studied the role of the serotonin 2C receptor (5-HTR) in weight regulation and behavior....
6.
Lindquist P, Gasbjerg L, Mokrosinski J, Holst J, Hauser A, Rosenkilde M
Front Endocrinol (Lausanne)
. 2022 Jul;
13:891586.
PMID: 35846282
The intestinal hormone, glucose-dependent insulinotropic polypeptide (GIP), is involved in important physiological functions, including postprandial blood glucose homeostasis, bone remodeling, and lipid metabolism. While mutations leading to physiological changes can...
7.
Mendes de Oliveira E, Keogh J, Talbot F, Henning E, Ahmed R, Perdikari A, et al.
N Engl J Med
. 2021 Oct;
385(17):1581-1592.
PMID: 34614324
Background: encodes the Gα (stimulatory G-protein alpha subunit) protein, which mediates G protein-coupled receptor (GPCR) signaling. mutations cause developmental delay, short stature, and skeletal abnormalities in a syndrome called Albright's...
8.
Wade K, Lam B, Melvin A, Pan W, Corbin L, Hughes D, et al.
Nat Med
. 2021 May;
27(6):1088-1096.
PMID: 34045736
Mutations in the melanocortin 4 receptor gene (MC4R) are associated with obesity but little is known about the prevalence and impact of such mutations throughout human growth and development. We...
9.
Brouwers B, Mendes de Oliveira E, Marti-Solano M, Monteiro F, Laurin S, Keogh J, et al.
Cell Rep
. 2021 Mar;
34(12):108862.
PMID: 33761344
The Melanocortin-4 Receptor (MC4R) plays a pivotal role in energy homeostasis. We used human MC4R mutations associated with an increased or decreased risk of obesity to dissect mechanisms that regulate...
10.
Lotta L, Mokrosinski J, Mendes de Oliveira E, Li C, Sharp S, Luan J, et al.
Cell
. 2019 Apr;
177(3):597-607.e9.
PMID: 31002796
The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor whose disruption causes obesity. We functionally characterized 61 MC4R variants identified in 0.5 million people from UK Biobank and examined...