Jacek Mokrosinski
Overview
Explore the profile of Jacek Mokrosinski including associated specialties, affiliations and a list of published articles.
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27
Citations
778
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Recent Articles
11.
Rudenko O, Shang J, Munk A, Ekberg J, Petersen N, Engelstoft M, et al.
Mol Metab
. 2018 Nov;
19:49-64.
PMID: 30472415
Objectives: GPR142, which is highly expressed in pancreatic islets, has recently been deorphanized as a receptor for aromatic amino acids; however, its physiological role and pharmacological potential is unclear. Methods...
12.
Clement K, Biebermann H, Farooqi I, van der Ploeg L, Wolters B, Poitou C, et al.
Nat Med
. 2018 May;
24(5):551-555.
PMID: 29736023
Genetic defects underlying the melanocortin-4 receptor (MC4R) signaling pathway lead to severe obesity. Three severely obese LEPR-deficient individuals were administered the MC4R agonist setmelanotide, resulting in substantial and durable reductions...
13.
Syed I, Lee J, Moraes-Vieira P, Donaldson C, Sontheimer A, Aryal P, et al.
Cell Metab
. 2018 Feb;
27(2):419-427.e4.
PMID: 29414687
Palmitic acid hydroxystearic acids (PAHSAs) are endogenous lipids with anti-diabetic and anti-inflammatory effects. PAHSA levels are reduced in serum and adipose tissue of insulin-resistant people and high-fat diet (HFD)-fed mice....
14.
Collet T, Dubern B, Mokrosinski J, Connors H, Keogh J, Mendes de Oliveira E, et al.
Mol Metab
. 2017 Oct;
6(10):1321-1329.
PMID: 29031731
Objective: Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanotide is a highly potent MC4R agonist that leads to weight loss in...
15.
Nohr A, Shehata M, Hauser A, Isberg V, Mokrosinski J, Andersen K, et al.
Neurochem Int
. 2016 Dec;
102:105-113.
PMID: 27916541
GPR139 is an orphan G protein-coupled receptor that is expressed primarily in the brain. Not much is known regarding the function of GPR139. Recently we have shown that GPR139 is...
16.
Valentin-Hansen L, Frimurer T, Mokrosinski J, Holliday N, Schwartz T
J Biol Chem
. 2015 Aug;
290(40):24495-508.
PMID: 26269596
X-ray structures, molecular dynamics simulations, and mutational analysis have previously indicated that an extended water hydrogen bond network between trans-membranes I-III, VI, and VII constitutes an allosteric interface essential for...
17.
Els S, Schild E, Petersen P, Kilian T, Mokrosinski J, Frimurer T, et al.
J Med Chem
. 2012 Aug;
55(17):7437-49.
PMID: 22920150
The ghrelin receptor displays a high constitutive activity suggested to be involved in the regulation of appetite and food intake. Here, we have created peptides with small changes in the...
18.
Mokrosinski J, Frimurer T, Sivertsen B, Schwartz T, Holst B
J Biol Chem
. 2012 Aug;
287(40):33488-502.
PMID: 22846991
Based on a rare, natural Glu for Ala-204(C+6) variant located six residues after the conserved Cys residue in extracellular loop 2b (ECL2b) associated with selective elimination of the high constitutive...
19.
Zakrzewski P, Cygankiewicz A, Mokrosinski J, Nowacka-Zawisza M, Semczuk A, Rechberger T, et al.
Oncology
. 2011 Nov;
81(3-4):243-50.
PMID: 22116456
Objective: Alterations in the transforming growth factor-β (TGF-β) signaling cascade are engaged in the development of human neoplasms through the deregulation of proliferation, differentiation and migration. However, in endometrial cancer,...
20.
Benned-Jensen T, Mokrosinski J, Rosenkilde M
PLoS One
. 2011 Sep;
6(9):e24644.
PMID: 21931793
Background: The melanocortin 1 receptor (MC1R) constitutes a key regulator of melanism. Consequently, many naturally-occurring MC1R mutations are associated with a change in color. An example is the Glu-to-Lys substitution...