Jaap D van Buul
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Explore the profile of Jaap D van Buul including associated specialties, affiliations and a list of published articles.
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116
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3057
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Recent Articles
21.
Schoppmeyer R, van Steen A, Kempers L, Timmerman A, Nolte M, Hombrink P, et al.
Cell Rep
. 2022 Jan;
38(3):110243.
PMID: 35045291
Understanding how cytotoxic T lymphocytes (CTLs) efficiently leave the circulation to target cancer cells or contribute to inflammation is of high medical interest. Here, we demonstrate that human central memory...
22.
Goedhart M, Slot E, Pascutti M, Geerman S, Rademakers T, Nota B, et al.
Cells
. 2022 Jan;
11(1).
PMID: 35011617
Apart from controlling hematopoiesis, the bone marrow (BM) also serves as a secondary lymphoid organ, as it can induce naïve T cell priming by resident dendritic cells (DC). When analyzing...
23.
van der Linden F, Mahlandt E, Arts J, Beumer J, Puschhof J, de Man S, et al.
Nat Commun
. 2021 Dec;
12(1):7159.
PMID: 34887382
The most successful genetically encoded calcium indicators (GECIs) employ an intensity or ratiometric readout. Despite a large calcium-dependent change in fluorescence intensity, the quantification of calcium concentrations with GECIs is...
24.
Rodenburg W, van Buul J
Vasc Biol
. 2021 Nov;
3(1):R77-R95.
PMID: 34738075
Rho GTPases are small signalling G-proteins that are central regulators of cytoskeleton dynamics, and thereby regulate many cellular processes, including the shape, adhesion and migration of cells. As such, Rho...
25.
van Steen A, Kempers L, Schoppmeyer R, Blokker M, Beebe D, Nolte M, et al.
J Cell Sci
. 2021 Oct;
134(21).
PMID: 34622930
Leukocyte extravasation into inflamed tissue is a complex process that is difficult to capture as a whole in vitro. We employed a blood-vessel-on-a-chip model in which human endothelial cells were...
26.
Kempers L, Driessen A, van Rijssel J, Nolte M, van Buul J
Int J Mol Sci
. 2021 Sep;
22(18).
PMID: 34576329
Many cellular processes are controlled by small GTPases, which can be activated by guanine nucleotide exchange factors (GEFs). The RhoGEF Trio contains two GEF domains that differentially activate the small...
27.
Arts J, Mahlandt E, Gronloh M, Schimmel L, Noordstra I, Gordon E, et al.
Elife
. 2021 Aug;
10.
PMID: 34431475
Upon inflammation, leukocytes rapidly transmigrate across the endothelium to enter the inflamed tissue. Evidence accumulates that leukocytes use preferred exit sites, alhough it is not yet clear how these hotspots...
28.
Mahlandt E, Arts J, van der Meer W, van der Linden F, Tol S, van Buul J, et al.
J Cell Sci
. 2021 Aug;
134(17).
PMID: 34357388
Rho GTPases are regulatory proteins, which orchestrate cell features such as morphology, polarity and movement. Therefore, probing Rho GTPase activity is key to understanding processes such as development and cell...
29.
Kempers L, Sprenkeler E, van Steen A, van Buul J, Kuijpers T
Front Immunol
. 2021 Jun;
12:678030.
PMID: 34135903
The actin-related protein (ARP) 2/3 complex, essential for organizing and nucleating branched actin filaments, is required for several cellular immune processes, including cell migration and granule exocytosis. Recently, genetic defects...
30.
Arts J, Mahlandt E, Schimmel L, Gronloh M, Niet S, Klein B, et al.
Front Immunol
. 2021 Jun;
12:667213.
PMID: 34084168
An inflammatory response requires leukocytes to migrate from the circulation across the vascular lining into the tissue to clear the invading pathogen. Whereas a lot of attention is focused on...