J W Pettegrew
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Explore the profile of J W Pettegrew including associated specialties, affiliations and a list of published articles.
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94
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1772
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Recent Articles
1.
Levine J, Panchalingam K, McClure R, Gershon S, Pettegrew J
Neurochem Res
. 2003 Apr;
28(5):687-90.
PMID: 12716017
Acetyl-L-carnitine (ALCAR) and myo-inositol are reported to enhance motor activity in animal models; modulate membrane phospholipid metabolism (ALCAR and myo-inositol) and high-energy phosphate metabolism (ALCAR) back to normal; and be...
2.
Keshavan M, Stanley J, Montrose D, Minshew N, Pettegrew J
Mol Psychiatry
. 2003 Mar;
8(3):316-23, 251.
PMID: 12660804
In vivo (31)P magnetic resonance spectroscopy ((31)P MRS) studies have shown abnormal membrane phospholipid metabolism in the prefrontal cortex (PF) in the early course of schizophrenia. It is unclear, however,...
3.
Keshavan M, Diwadkar V, Harenski K, Rosenberg D, Sweeney J, Pettegrew J
J Neurol Neurosurg Psychiatry
. 2002 May;
72(6):757-60.
PMID: 12023420
Background: Structural alterations in the association cortices as well as in the corpus callosum (CC) have been described in schizophrenia, and have been considered to reflect developmental abnormalities. Areas of...
4.
Pettegrew J, Panchalingam K, Hamilton R, McClure R
Neurochem Res
. 2001 Sep;
26(7):771-82.
PMID: 11565608
Studies have demonstrated alterations in brain membrane phospholipid metabolite levels in Alzheimer's disease (AD). The changes in phospholipid metabolite levels correlate with neuropathological hallmarks of the disease and measures of...
5.
Pettegrew J, Panchalingam K, McClure R, Gershon S, Muenz L, Levine J
Bipolar Disord
. 2001 Sep;
3(4):189-201.
PMID: 11552958
Objective: There is evidence linking affective disorders and their treatment to alterations in membrane phospholipid metabolism, the phosphatidylinositol (PtdIns) second messenger cycle and brain excitatory and inhibitory amino acids. This...
6.
Pettegrew J, Panchalingam K, McClure R, Levine J
Neurochem Res
. 2001 Aug;
26(2):181-5.
PMID: 11478746
(-)Nicotine acetylcholine receptors are located on both nerve cell bodies and synaptic terminals, are permeable to calcium, and function perhaps predominantly by facilitating the release of neurotransmitters and neuropeptides. The...
7.
Pettegrew J, Panchalingam K, Levine J, McClure R, Gershon S, Yao J
Biol Psychiatry
. 2001 Mar;
49(5):444-53.
PMID: 11274656
Background: Oral myo-inositol (12--18 g/day) has shown beneficial effect in placebo-controlled studies of major depression, panic disorder, and obsessive compulsive disorder, and preliminary data suggest it also may be effective...
8.
Stanley J, Pettegrew J
Magn Reson Med
. 2001 Mar;
45(3):390-6.
PMID: 11241695
In a typical, in vivo (31)P brain spectrum, the phosphomonoester (PME) and phosphodiester (PDE) spectral region not only contains signals from freely mobile PMEs and PDEs (which are anabolic and...
9.
Pettegrew J, Klunk W, Panchalingam K, McClure R, Stanley J
Brain Res Bull
. 2001 Jan;
53(4):455-69.
PMID: 11137004
Magnetic resonance spectroscopy (MRS) is a non-invasive physical technique that is routinely used to determine the quantity and structure of organic molecules in solution. Technical advances that have expanded the...
10.
Pettegrew J, Levine J, McClure R
Mol Psychiatry
. 2000 Dec;
5(6):616-32.
PMID: 11126392
Acetyl-L-carnitine (ALCAR) contains carnitine and acetyl moieties, both of which have neurobiological properties. Carnitine is important in the beta-oxidation of fatty acids and the acetyl moiety can be used to...