J W Jetter
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Explore the profile of J W Jetter including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
8
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Recent Articles
1.
PITTS W, Wityak J, Smallheer J, Tobin A, Jetter J, Buynitsky J, et al.
J Med Chem
. 2000 Jan;
43(1):27-40.
PMID: 10633036
Starting with lead compound 2, we sought to increase the selectivity for alpha(v)beta(3)-mediated cell adhesion by examining the effects of structural changes in both the guanidine mimetic and the substituent...
2.
Pinto D, Batt D, PITTS W, Petraitis J, Orwat M, Wang S, et al.
Bioorg Med Chem Lett
. 1999 May;
9(7):919-24.
PMID: 10230611
The discovery of terphenyl derivatives as highly selective COX-2 inhibitors resulted from our efforts to overcome poor pharmacokinetics demonstrated by the COX-2 selective diarylthiophene DuP 697 [2-bromo-4-(4'-sulfonylmethyl)phenyl-5-(4'-fluoro)phenylthiophe ne]. Detailed SAR...
3.
PITTS W, Jetter J, Pinto D, Orwat M, Batt D, Sherk S, et al.
Bioorg Med Chem Lett
. 1999 Jan;
8(3):307-12.
PMID: 9871675
The structure-activity relationships of some tetracyclic heterocycles related to Brequinar were explored. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction are related to ring system, heteroatom placement,...