G C Houghton
Overview
Explore the profile of G C Houghton including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
10
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0
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Recent Articles
1.
Batt D, Houghton G, Daneker W, Jadhav P
J Org Chem
. 2000 Nov;
65(23):8100-4.
PMID: 11073629
No abstract available.
2.
Batt D, Petraitis J, Houghton G, Modi D, Cain G, Corjay M, et al.
J Med Chem
. 2000 Jan;
43(1):41-58.
PMID: 10633037
A new series of indazole-containing alpha(v)beta(3) integrin antagonists is described. Starting with lead compound 18a, variations in a number of structural features were explored with respect to inhibition of the...
3.
Pinto D, Batt D, PITTS W, Petraitis J, Orwat M, Wang S, et al.
Bioorg Med Chem Lett
. 1999 May;
9(7):919-24.
PMID: 10230611
The discovery of terphenyl derivatives as highly selective COX-2 inhibitors resulted from our efforts to overcome poor pharmacokinetics demonstrated by the COX-2 selective diarylthiophene DuP 697 [2-bromo-4-(4'-sulfonylmethyl)phenyl-5-(4'-fluoro)phenylthiophe ne]. Detailed SAR...
4.
Olson R, Sielecki T, Wityak J, Pinto D, Batt D, Frietze W, et al.
J Med Chem
. 1999 Apr;
42(7):1178-92.
PMID: 10197962
Modification of the alpha-carbamate substituent of isoxazoline GPIIb/IIIa (alphaIIb beta3) antagonist DMP 754 (7) led to a series of alpha-sulfonamide and alpha-sulfamide diaminopropionate isoxazolinylacetamides which were found to be potent...