J Vijayalakshmi
Overview
Explore the profile of J Vijayalakshmi including associated specialties, affiliations and a list of published articles.
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16
Citations
242
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Recent Articles
11.
Graumann J, Lilie H, Tang X, Tucker K, Hoffmann J, Vijayalakshmi J, et al.
Structure
. 2001 May;
9(5):377-87.
PMID: 11377198
Background: Hsp33 is a novel redox-regulated molecular chaperone. Hsp33 is present in the reducing environment of the cytosol and is, under normal conditions, inactive. The four highly conserved cysteines found...
12.
Vijayalakshmi J, Mukhergee M, Graumann J, Jakob U, Saper M
Structure
. 2001 May;
9(5):367-75.
PMID: 11377197
Background: One strategy that cells employ to respond to environmental stresses (temperature, oxidation, and pathogens) is to increase the expression of heat shock proteins necessary to maintain viability. Several heat...
13.
Denu J, Lohse D, Vijayalakshmi J, Saper M, Dixon J
Proc Natl Acad Sci U S A
. 1996 Mar;
93(6):2493-8.
PMID: 8637902
Engineering site-specific amino acid substitutions into the protein-tyrosine phosphatase (PTPase) PTP1 and the dual-specific vaccinia H1-related phosphatase (VHR), has kinetically isolated the two chemical steps of the reaction and provided...
14.
Vijayalakshmi J, Padmanabhan K, Mann K, Tulinsky A
Protein Sci
. 1994 Dec;
3(12):2254-71.
PMID: 7756983
The X-ray crystal structure of prethrombin2 (pre2), the immediate inactive precursor of alpha-thrombin, has been determined at 2.0 A resolution complexed with hirugen. The structure has been refined to a...
15.
Hernandez M, POWERS J, Glinski J, Oleksyszyn J, Vijayalakshmi J, Meyer Jr E
J Med Chem
. 1992 Mar;
35(6):1121-9.
PMID: 1552505
A series of new acyl, urea, and carbonate derivatives of 7-amino-4-chloro-3-methoxyisocoumarin were synthesized and evaluated as irreversible inhibitors of human neutrophil elastase (HNE) and porcine pancreatic elastase (PPE). Inhibition of...
16.
Vijayalakshmi J, Meyer Jr E, Kam C, POWERS J
Biochemistry
. 1991 Mar;
30(8):2175-83.
PMID: 1998677
The complex of porcine pancreatic elastase (PPE) with 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin, a potent mechanism-based inhibitor, was crystallized and the crystal structure determined at 1.9-A resolution with a final R factor of 17.1%....