Mark A Saper
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Explore the profile of Mark A Saper including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
170
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Recent Articles
1.
Kirillov S, Isupov M, Paterson N, Wiener R, Abeldenov S, Saper M, et al.
Biochemistry
. 2024 Dec;
64(1):67-82.
PMID: 39655415
During infections, reactive oxygen species cause DNA damage, including nucleotide base modification. After removal of the defective base, excision repair requires an endonuclease IV (Nfo), which hydrolyzes the phosphodiester bond...
2.
Larson M, Biddle K, Gorman A, Boutom S, Rosenshine I, Saper M
PLoS One
. 2021 Nov;
16(11):e0259900.
PMID: 34780538
Enteropathogenic Escherichia coli O127 is encapsulated by a protective layer of polysaccharide made of the same strain specific O-antigen as the serotype lipopolysaccharide. Seven genes encoding capsule export functions comprise...
3.
Shin J, Sulpizio A, Kelley A, Alvarez L, Murphy S, Fan L, et al.
Proc Natl Acad Sci U S A
. 2020 May;
117(21):11692-11702.
PMID: 32393643
Most bacteria surround themselves with a cell wall, a strong meshwork consisting primarily of the polymerized aminosugar peptidoglycan (PG). PG is essential for structural maintenance of bacterial cells, and thus...
4.
Heiss C, Wang Z, Thurlow C, Hossain M, Sun D, Liles M, et al.
Carbohydr Res
. 2019 Nov;
486:107858.
PMID: 31683071
A hypervirulent A. hydrophila (vAh) pathotype has been identified as the etiologic agent responsible for disease outbreaks in farmed carp species and channel catfish (Ictalurus punctatus) in China and the...
5.
Liepman A, Vijayalakshmi J, Peisach D, Hulsebus B, Olsen L, Saper M
Front Plant Sci
. 2019 Nov;
10:1229.
PMID: 31681359
Photorespiration is an energetically costly metabolic pathway for the recycling of phosphoglycolate produced by the oxygenase activity of ribulose-1,5-bisphosphate carboxylase/oxygenase (RUBISCO) to phosphoglycerate. alanine:glyoxylate aminotransferase 1 (AGT1) is a peroxisomal...
6.
Kelley A, Vijayalakshmi J, Saper M
Acta Crystallogr F Struct Biol Commun
. 2019 May;
75(Pt 5):368-376.
PMID: 31045566
The bacterial periplasmic protein LpoA is an outer membrane lipoprotein and an activator for the cross-linking activity of PBP1A, a bifunctional peptidoglycan synthase. Previous structures of the amino-terminal (N) domain...
7.
Sathiyamoorthy K, Vijayalakshmi J, Tirupati B, Fan L, Saper M
J Biol Chem
. 2017 Sep;
292(43):17626-17642.
PMID: 28887305
In many Gram-negative bacteria, the peptidoglycan synthase PBP1A requires the outer membrane lipoprotein LpoA for constructing a functional peptidoglycan required for bacterial viability. Previously, we have shown that the C-terminal...
8.
Nadler C, Koby S, Peleg A, Johnson A, Suddala K, Sathiyamoorthy K, et al.
PLoS One
. 2012 Jun;
7(6):e37984.
PMID: 22675501
Capsules frequently play a key role in bacterial interactions with their environment. Escherichia coli capsules were categorized as groups 1 through 4, each produced by a distinct mechanism. Etk and...
9.
Rojviriya C, Pratumrat T, Saper M, Yuvaniyama J
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2011 Dec;
67(Pt 12):1570-4.
PMID: 22139169
Penicillin G acylase from Bacillus megaterium (BmPGA) is currently used in the pharmaceutical industry as an alternative to PGA from Escherichia coli (EcPGA) for the hydrolysis of penicillin G to...
10.
Sathiyamoorthy K, Mills E, Franzmann T, Rosenshine I, Saper M
Biochemistry
. 2011 Apr;
50(24):5465-76.
PMID: 21449614
We report the 1.9 Å resolution crystal structure of enteropathogenic Escherichia coli GfcC, a periplasmic protein encoded by the gfc operon, which is essential for assembly of group 4 polysaccharide...