J U Bowie
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Explore the profile of J U Bowie including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Bowie J
Curr Opin Struct Biol
. 2001 Aug;
11(4):397-402.
PMID: 11495729
Membrane proteins can be extremely stable in a bilayer environment, but are often unstable and rapidly lose activity after detergent solubilization. Poor stability can preclude the detailed characterization of many...
2.
Kim C, Phillips M, Kim W, Gingery M, Tran H, Robinson M, et al.
EMBO J
. 2001 Aug;
20(15):4173-82.
PMID: 11483520
TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain...
3.
Zhou Y, Lau F, Nauli S, Yang D, Bowie J
Protein Sci
. 2001 Mar;
10(2):378-83.
PMID: 11266623
We have examined the irreversible inactivation mechanism of the membrane protein diacylglycerol kinase in the detergents n-octyl-beta-D-glucopyranoside (OG) at 55 degrees C and n-decyl-maltopyranoside (DM) at 80 degrees C. Under...
4.
5.
Nagy J, Lau F, Bowie J, Sanders C
Biochemistry
. 2000 Apr;
39(14):4154-64.
PMID: 10747807
This work represents the first stage of thiol-based cross-linking studies to map the oligomeric interface of the homotrimeric membrane protein diacylglycerol kinase (DAGK). A total of 53 single-cysteine mutants spanning...
6.
Zhou Y, Bowie J
J Biol Chem
. 2000 Mar;
275(10):6975-9.
PMID: 10702260
The poor stability of membrane proteins in detergent solution is one of the main technical barriers to their structural and functional characterization. Here we describe a solution to this problem...
7.
Bowie J
Nat Struct Biol
. 2000 Feb;
7(2):91-4.
PMID: 10655604
In contrast to soluble proteins, the primary interactions that specify and stabilize membrane protein structures are still largely a matter of speculation. Although van der Waals interactions have been gaining...
8.
Bowie J
Protein Sci
. 2000 Jan;
8(12):2711-9.
PMID: 10631987
In the fold recognition approach to structure prediction, a sequence is tested for compatibility with an already known fold. For membrane proteins, however, few folds have been determined experimentally. Here...
9.
Thanos C, Faham S, Goodwill K, Cascio D, Phillips M, Bowie J
J Biol Chem
. 1999 Dec;
274(52):37301-6.
PMID: 10601296
The sterile alpha motif (SAM) domain is a protein module found in many diverse signaling proteins. SAM domains in some systems have been shown to self-associate. Previous crystal structures of...
10.
Thanos C, Bowie J
Protein Sci
. 1999 Aug;
8(8):1708-10.
PMID: 10452616
Homologs of the tumor suppressor p53, called p63 and p73, have been identified. The p63 and p73 family members possess a domain structure similar to p53, but contain variable C-terminal...