J F Reidhaar-Olson
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Explore the profile of J F Reidhaar-Olson including associated specialties, affiliations and a list of published articles.
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11
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313
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Recent Articles
1.
Friess H, Ding J, Kleeff J, Fenkell L, Rosinski J, Guweidhi A, et al.
Cell Mol Life Sci
. 2003 Jul;
60(6):1180-99.
PMID: 12861384
Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. To improve diagnosis and treatment, key mechanisms of deregulated molecular functions have to be identified. Using microarray analysis, the expression patterns...
2.
Reidhaar-Olson J, Rhees B, Hammer J
J Cell Biochem Suppl
. 2002 Feb;
Suppl 37:110-9.
PMID: 11842436
New approaches to drug discovery have come about in recent years as a result of important advances in genomics and bioinformatics. The availability of genome-scale sequence data, the development of...
3.
Gore M, Morshedi M, Reidhaar-Olson J
Funct Integr Genomics
. 2002 Jan;
1(2):114-26.
PMID: 11793227
In order to investigate gene expression changes associated with cytotoxicity, we used cDNA arrays to monitor the expression of over 5,000 genes in response to toxic stress in the HepG2...
4.
Sharkov N, Davis R, Reidhaar-Olson J, Navre M, Cai D
J Biol Chem
. 2001 Jan;
276(14):10788-93.
PMID: 11152696
Peptide libraries generated using phage display have been widely applied to proteolytic enzymes for substrate selection and optimization, but the reaction kinetics between the enzyme and substrate phage are not...
5.
Reidhaar-Olson J, Davis R, Selick H
Mol Cell Endocrinol
. 2000 Mar;
160(1-2):135-47.
PMID: 10715547
We used site-directed mutagenesis to construct 55 single-site variants of rhPTH, a recombinantly-expressed form of human parathyroid hormone (1-34) containing three amino acid changes compared to the natural sequence (ML8,...
6.
Reidhaar-Olson J, Selick H
Biochemistry
. 1996 Jul;
35(28):9034-41.
PMID: 8703906
Alanine scanning mutagenesis of human granulocyte colony-stimulating factor (G-CSF) was used to identify residues critical for the cell-proliferative activity of the protein. Fifty-eight residues, most of them on the protein...
7.
Reidhaar-Olson J, Bowie J, Breyer R, Hu J, Knight K, Lim W, et al.
Methods Enzymol
. 1991 Jan;
208:564-86.
PMID: 1779849
No abstract available.
8.
Reidhaar-Olson J, Parsell D, Sauer R
Biochemistry
. 1990 Aug;
29(33):7563-71.
PMID: 2148681
Pro78 is a solvent-exposed residue at the N-terminal end of alpha-helix 5 in the DNA binding domain of lambda repressor. Random mutagenesis experiments have suggested that Pro78 is essential [Reidhaar-Olson,...
9.
Bowie J, Reidhaar-Olson J, Lim W, Sauer R
Science
. 1990 Mar;
247(4948):1306-10.
PMID: 2315699
An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins...
10.
Reidhaar-Olson J, Sauer R
Proteins
. 1990 Jan;
7(4):306-16.
PMID: 2199970
A method of targeted random mutagenesis has been used to investigate the informational content of 25 residue positions in two alpha-helical regions of the N-terminal domain of lambda repressor. Examination...