J Rafael Godinez-Fernandez
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Explore the profile of J Rafael Godinez-Fernandez including associated specialties, affiliations and a list of published articles.
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9
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41
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Recent Articles
1.
Felix-Martinez G, Osorio-Londono D, Godinez-Fernandez J
PLoS Comput Biol
. 2024 Aug;
20(8):e1012357.
PMID: 39137218
The experimental study and transplantation of pancreatic islets requires their isolation from the surrounding tissue, and therefore, from the vasculature. Under these conditions, avascular islets rely on the diffusion of...
2.
Felix-Martinez G, Godinez-Fernandez J
Islets
. 2023 Jul;
15(1):2231609.
PMID: 37415423
Pancreatic islets are mini-organs composed of hundreds or thousands of ɑ, β and δ-cells, which, respectively, secrete glucagon, insulin and somatostatin, key hormones for the regulation of blood glucose. In...
3.
Felix-Martinez G, Nicolas-Mata A, Godinez-Fernandez J
J Vis Exp
. 2022 Mar;
(181).
PMID: 35343963
Structural properties of pancreatic islets are key for the functional response of insulin, glucagon, and somatostatin-secreting cells, due to their implications in intraislet communication via electric, paracrine, and autocrine signaling....
4.
Felix-Martinez G, N Mata A, Godinez-Fernandez J
Islets
. 2020 Oct;
12(6):121-133.
PMID: 33090076
We outline a general methodology based on computational optimization and experimental data to reconstruct human pancreatic islet architectures. By using the nuclei coordinates of islet cells obtained through DAPI staining,...
5.
Juayerk-Herrera K, Felix-Martinez G, Picones A, Del-Rio-Correa J, Godinez-Fernandez J
J Theor Biol
. 2020 Sep;
508:110459.
PMID: 32890554
As a complement to the experimental work, mathematical models are extensively used to study the functional properties of ionic channels. Even though it is generally assumed that the gating of...
6.
Felix-Martinez G, Gonzalez-Velez V, Godinez-Fernandez J, Gil A
Int J Numer Method Biomed Eng
. 2019 Dec;
36(2):e3296.
PMID: 31833669
Minimal mathematical models were developed to describe the electrophysiological properties of human δ-cells. Markov models of single channels were first developed based on the analysis of electrophysiological data. Monte Carlo...
7.
Felix-Martinez G, Godinez-Fernandez J
Endocrinol Diabetes Nutr (Engl Ed)
. 2018 Jun;
65(10):603-610.
PMID: 29945768
Background: Prevalence of diabetes in Mexico has constantly increased since 1993. Since type 2 diabetes may remain undiagnosed for many years, identification of subjects at high risk of diabetes is...
8.
Felix-Martinez G, Godinez-Fernandez J
Math Biosci
. 2015 Oct;
270(Pt A):66-80.
PMID: 26476144
Macroscopic Ca(2+) currents of the human β-cells were characterized using the Hodgkin-Huxley formalism. Expressions describing the Ca(2+)-dependent inactivation process of the L-type Ca(2+) channels in terms of the concentration of...
9.
Felix-Martinez G, Godinez-Fernandez J
Islets
. 2014 Oct;
6(3):e949195.
PMID: 25322829
Mathematical modeling of the electrical activity of the pancreatic β-cell has been extremely important for understanding the cellular mechanisms involved in glucose-stimulated insulin secretion. Several models have been proposed over...