J R Seals
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Explore the profile of J R Seals including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
242
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Recent Articles
1.
Ma J, Bulger P, Davis D, Bedore D, Kensil C, Young E, et al.
Vaccine
. 1994 Aug;
12(10):925-32.
PMID: 7975834
The impact of the adjuvants QS-21 and aluminium hydroxide (alum) on the immunogenicity of recombinant outer surface proteins A (OspA) and B (OspB) of Borrelia burgdorferi was investigated. Both non-acylated...
2.
Newman M, Munroe K, Anderson C, Murphy C, Panicali D, Seals J, et al.
AIDS Res Hum Retroviruses
. 1994 Jul;
10(7):853-61.
PMID: 7986590
Subunit vaccines based on recombinant proteins have proved useful for inducing antibody responses and they are safe for widespread use because they do not contain any live components. Unfortunately, they...
3.
Yeh J, Seals J, Murphy C, van Halbeek H, Cummings R
Biochemistry
. 1993 Oct;
32(41):11087-99.
PMID: 8218172
We report the complete structures of the N-linked oligosaccharides and the site-specificity of the N-glycosylation of recombinant gp120 (rgp120) of the HIV-1 BH8 isolate produce by a baculovirus expression system....
4.
Murphy C, McIntire J, Davis D, Hodgdon H, Seals J, Young E
Protein Expr Purif
. 1993 Oct;
4(5):349-57.
PMID: 8251745
The expression of glycosylated and secreted recombinant mammalian proteins in baculovirus-infected insect cells is often much less efficient than that of other foreign proteins in this system. In an effort...
5.
Newman M, Wu J, Coughlin R, Murphy C, Seals J, Wyand M, et al.
AIDS Res Hum Retroviruses
. 1992 Aug;
8(8):1413-8.
PMID: 1466970
A highly purified saponin from Q. saponaria (QS-21) was tested in juvenile rhesus macaques for adjuvant activity and toxicity. The QS-21 was tested alone or as part of an experimental...
6.
Wu J, Gardner B, Murphy C, Seals J, Kensil C, Recchia J, et al.
J Immunol
. 1992 Mar;
148(5):1519-25.
PMID: 1538134
The adjuvant activity of a single highly purified saponin from the soap bark tree Quillaja saponaria was evaluated by using it as a component in an experimental vaccine containing rHIV-1...
7.
Wu J, Riggin C, Seals J, Murphy C, Newman M
J Immunol Methods
. 1991 Sep;
143(1):1-9.
PMID: 1717603
Recombinant proteins representing full-length and truncated forms of the human immunodeficiency virus type 1 envelope protein gp160 were produced in E. coli and sf9 insect cells. These proteins were denatured...
8.
Czech M, Yu K, Seals J
Diabetes Care
. 1984 May;
7 Suppl 1:8-16.
PMID: 6376032
Cellular signaling by insulin is initiated by specific membrane receptors that have been characterized as large multimeric disulfide-linked protein complexes with a minimal subunit structure of (beta-S-S-alpha)-S-S-(alpha-S-S-beta), where the alpha-...
9.
Seals J, Czech M
Fed Proc
. 1982 Sep;
41(11):2730-5.
PMID: 6811328
Purified rat adipocyte plasma membranes incubated with insulin produce a soluble chemical mediator that stimulates pyruvate dehydrogenase when added to isolated mitochondria, or glycogen synthase when added to cell homogenates....
10.