J R Hepler
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Explore the profile of J R Hepler including associated specialties, affiliations and a list of published articles.
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44
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1611
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Recent Articles
1.
Harbin N, Lustberg D, Hurst C, Pare J, Crotty K, Waters A, et al.
Neurobiol Dis
. 2023 Apr;
181:106128.
PMID: 37075948
RGS14 is a complex multifunctional scaffolding protein that is highly enriched within pyramidal cells (PCs) of hippocampal area CA2. In these neurons, RGS14 suppresses glutamate-induced calcium influx and related G...
2.
RGS14 is a bifunctional regulator of Galphai/o activity that exists in multiple populations in brain
Hollinger S, Taylor J, Goldman E, Hepler J
J Neurochem
. 2001 Dec;
79(5):941-9.
PMID: 11739605
Members of the regulators of G protein signaling (RGS) family modulate Galpha-directed signals as a result of the GTPase-activating protein (GAP) activity of their conserved RGS domain. In addition to...
3.
Cunningham M, Waldo G, Hollinger S, Hepler J, Harden T
J Biol Chem
. 2000 Nov;
276(8):5438-44.
PMID: 11063746
RGS proteins (regulators of G protein signaling) attenuate heterotrimeric G protein signaling by functioning as both GTPase-activating proteins (GAPs) and inhibitors of G protein/effector interaction. RGS2 has been shown to...
4.
Rose J, Taylor J, Shi J, Cockett M, Jones P, Hepler J
J Neurochem
. 2000 Oct;
75(5):2103-12.
PMID: 11032900
Regulator of G protein signaling (RGS) proteins are GTPase-activating proteins that modulate neurotransmitter and G protein signaling. RGS7 and its binding partners Galpha and Gbeta5 are enriched in brain, but...
5.
Heximer S, Srinivasa S, Bernstein L, Bernard J, Linder M, Hepler J, et al.
J Biol Chem
. 1999 Nov;
274(48):34253-9.
PMID: 10567399
RGS (regulator of G protein signaling) proteins are GTPase-activating proteins that attenuate signaling by heterotrimeric G proteins. Whether the biological functions of RGS proteins are governed by quantitative differences in...
6.
Hepler J
Trends Pharmacol Sci
. 1999 Aug;
20(9):376-82.
PMID: 10462761
Regulators of G-protein signalling (RGS proteins) are a family of highly diverse, multifunctional signalling proteins that share a conserved 120 amino acid domain (RGS domain). RGS domains bind directly to...
7.
Saugstad J, Marino M, Folk J, Hepler J, Conn P
J Neurosci
. 1998 Feb;
18(3):905-13.
PMID: 9437012
Metabotropic glutamate receptors (mGluRs) couple to heterotrimeric G-proteins and regulate cell excitability and synaptic transmission in the CNS. Considerable effort has been focused on understanding the cellular and biochemical mechanisms...
8.
Heximer S, Watson N, Linder M, Blumer K, Hepler J
Proc Natl Acad Sci U S A
. 1998 Feb;
94(26):14389-93.
PMID: 9405622
RGS (regulators of G protein signaling) proteins are GTPase activating proteins that inhibit signaling by heterotrimeric G proteins. All RGS proteins studied to date act on members of the Gialpha...
9.
Huang C, Hepler J, Chen L, GILMAN A, Anderson R, Mumby S
Mol Biol Cell
. 1997 Dec;
8(12):2365-78.
PMID: 9398661
There is mounting evidence for the organization and compartmentation of signaling molecules at the plasma membrane. We find that hormone-sensitive adenylyl cyclase activity is enriched in a subset of regulatory...
10.
Huang C, Hepler J, GILMAN A, Mumby S
Proc Natl Acad Sci U S A
. 1997 Jun;
94(12):6159-63.
PMID: 9177187
Protein regulators of G protein signaling (RGS proteins) were discovered as negative regulators of heterotrimeric G protein-mediated signal transduction in yeast and worms. Experiments with purified recombinant proteins in vitro...