J R Hassell
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Explore the profile of J R Hassell including associated specialties, affiliations and a list of published articles.
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124
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3404
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Recent Articles
1.
Fukuchi K, Hart M, Yan Z, Hassell J, Li L
Histol Histopathol
. 2004 May;
19(3):845-52.
PMID: 15168347
Heparan sulfate proteoglycans such as perlecan are thought to facilitate amyloid fibril formation. Tg3695 mice overexpress perlecan core protein in many tissues including the brain and pancreas. Tg13592 mice overexpress...
2.
Hart M, Li L, Tokunaga T, Lindsey J, Hassell J, Snow A, et al.
J Pathol
. 2001 Jun;
194(2):262-9.
PMID: 11400157
Heparan sulphate proteoglycan (HSPG) and amyloid P component are the only macromolecules consistently associated with all varieties of amyloid, irrespective of the type of amyloid protein, suggesting that HSPG may...
3.
Berryhill B, Beales M, Hassell J
Invest Ophthalmol Vis Sci
. 2001 May;
42(6):1201-7.
PMID: 11328728
Purpose: To characterize the major proteoglycans produced and secreted by collagenase-isolated bovine keratocytes in culture. Methods: Freshly isolated keratocytes from mature bovine corneas were cultured in serum-free Dulbecco's modified Eagle's...
4.
Arikawa-Hirasawa E, Wilcox W, Le A, Silverman N, Govindraj P, Hassell J, et al.
Nat Genet
. 2001 Mar;
27(4):431-4.
PMID: 11279527
Perlecan is a large heparan sulfate (HS) proteoglycan present in all basement membranes and in some other tissues such as cartilage, and is implicated in cell growth and differentiation. Mice...
5.
Corpuz L, Dunlevy J, Hassell J, Conrad A, Conrad G
Matrix Biol
. 2000 Dec;
19(7):699-704.
PMID: 11102759
We have cloned and sequenced the cDNAs for quail cornea proteoglycan core proteins, decorin and lumican. Comparison of deduced amino acid sequences shows that two of five amino acid differences...
6.
Corpuz L, Dunlevy J, Hassell J, Conrad A, Conrad G
Matrix Biol
. 2000 Dec;
19(7):693-8.
PMID: 11102758
We have cloned and sequenced the cDNAs for quail cornea keratan sulfate proteoglycan core proteins, keratocan and mimecan. The deduced quail keratocan protein contains a single conservative amino acid difference...
7.
Chakravarti S, Petroll W, Hassell J, Jester J, Lass J, Paul J, et al.
Invest Ophthalmol Vis Sci
. 2000 Sep;
41(11):3365-73.
PMID: 11006226
Purpose: Gene targeted lumican-null mutants (lum(tm1sc)/lum(tm1sc)) have cloudy corneas with abnormally thick collagen fibrils. The purpose of the present study was to analyze the loss of transparency quantitatively and to...
8.
Neame P, Kay C, McQuillan D, Beales M, Hassell J
Cell Mol Life Sci
. 2000 Jul;
57(5):859-63.
PMID: 10892350
The leucine-rich proteoglycans (also known as "small, leucine-rich proteoglycans," or SLRPs) lumican and decorin are thought to be involved in the regulation of collagen fibril assembly. Preparation of these proteoglycans...
9.
Dunlevy J, Beales M, Berryhill B, Cornuet P, Hassell J
Exp Eye Res
. 2000 Mar;
70(3):349-62.
PMID: 10712821
The corneal proteoglycans belong to the Leu-rich proteoglycan (LRP) gene family and contain chondroitin/dermatan (CS/DS) or keratan sulfate (KS) chains. These proteoglycans play a critical role in generating and maintaining...
10.
Dunlevy J, Berryhill B, Vergnes J, Sundarraj N, Hassell J
Genomics
. 2000 Jan;
62(3):519-24.
PMID: 10644451
The cornea contains, as a major element, a transparent stroma produced and maintained by keratocytes (fibroblasts). Through molecular biology studies using cultured human corneal fibroblasts, a cDNA that was shown...