J R Coggins
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Explore the profile of J R Coggins including associated specialties, affiliations and a list of published articles.
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121
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1336
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Recent Articles
1.
Mousdale D, Coggins J
Planta
. 2013 Nov;
160(1):78-83.
PMID: 24258375
5-Enolpyruvylshikimate 3-phosphate synthase (3-phosphoshikimate 1-carboxyvinyltransferase; EC 2.5.1.19) from shoot tissue of pea seedlings was purified to apparent homogeneity by sequential ammonium-sulphate precipitation, ion-exchange and hydrophobic-interaction chromatography and substrate elution from...
2.
Mousdale D, Coggins J
Planta
. 2013 Nov;
163(2):241-9.
PMID: 24249346
5-Enolpyruvylshikimate 3-phosphate (EPSP) synthase (3-phosphoshikimate 1-carboxyvinyltransferase; EC 2.5.1.19), 3-dehydroquinate dehydratase (EC 4.2.1.10) and shikimate: NADP(+) oxidoreductase (EC 1.1.1.25) were present in intact chloroplasts and root plastids isolated from pea seedling...
3.
Powell H, Kerby N, Rowell P, Mousdale D, Coggins J
Planta
. 2013 Nov;
188(4):484-90.
PMID: 24178379
5-Enolpyruvylshikimate 3-phosphate (EPSP) synthase (3-phosphoshikimate 1-carboxyvinyltransferase; EC 2.5.1.9) from the glyphosate-tolerant cyanobacterium Anabaena variabilis (ATCC 29413) was purified to homogeneity. The enzyme had a similar relative molecular mass to other...
4.
Krell T, Coyle J, Horsburgh M, Coggins J, Lapthorn A
Acta Crystallogr D Biol Crystallogr
. 2004 Aug;
53(Pt 5):612-4.
PMID: 15299895
Shikimate kinase from Erwinia chrysanthemi, overexpressed in Escherichia coli has been crystallized by the vapour-diffusion method using sodium chloride as a precipitant. Mass spectrometry was used to confirm the purity...
5.
Campbell S, Richards T, Mui E, Samuel B, Coggins J, McLeod R, et al.
Int J Parasitol
. 2004 Jan;
34(1):5-13.
PMID: 14711585
The shikimate pathway is essential for survival of the apicomplexan parasites Plasmodium falciparum, Toxoplasma gondii and Cryptosporidium parvum. As it is absent in mammals it is a promising therapeutic target....
6.
Coggins J, ABELL C, Evans L, FREDERICKSON M, Robinson D, Roszak A, et al.
Biochem Soc Trans
. 2003 May;
31(Pt 3):548-52.
PMID: 12773154
The background and current context of work on the shikimate-pathway enzymes as potential targets for anti-bacterial, anti-fungal and anti-parasitic drugs is reviewed. Recent work on the third enzyme of the...
7.
Brown K, Carpenter E, Watson K, Coggins J, Hawkins A, Koch M, et al.
Biochem Soc Trans
. 2003 May;
31(Pt 3):543-7.
PMID: 12773153
We are studying two enzymes from the shikimate pathway, dehydroquinate synthase (DHQS) and 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). Both enzymes have been the subject of numerous studies to elucidate their reaction mechanisms....
8.
Krell T, Maclean J, Boam D, Cooper A, Resmini M, Brocklehurst K, et al.
Protein Sci
. 2001 May;
10(6):1137-49.
PMID: 11369852
Shikimate kinase, despite low sequence identity, has been shown to be structurally a member of the nucleoside monophosphate (NMP) kinase family, which includes adenylate kinase. In this paper we have...
9.
Lohkamp B, Coggins J, Lapthorn A
Acta Crystallogr D Biol Crystallogr
. 2001 Feb;
56(Pt 11):1488-91.
PMID: 11185885
ATP-phosphoribosyltransferase (ATP-PRT) from Escherichia coli has been purified and crystals were obtained by the vapour-diffusion method using sodium tartrate as a precipitant. Dynamic light scattering was used to assess conditions...
10.
Levett L, Liddle S, Wheeler K, Smith D, Lamb H, Newton G, et al.
Biochem J
. 2000 Aug;
350 Pt 1:189-97.
PMID: 10926843
QUTR (qutR-encoded transcription-repressing protein) is a multi-domain repressor protein active in the signal-transduction pathway that regulates transcription of the quinic acid utilization (qut) gene cluster in Aspergillus nidulans. In the...