C Kleanthous
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Explore the profile of C Kleanthous including associated specialties, affiliations and a list of published articles.
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63
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1316
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Recent Articles
1.
White G, Ottignon L, Georgiou T, Kleanthous C, MOORE G, Thomson A, et al.
J Magn Reson
. 2007 Jan;
185(2):191-203.
PMID: 17218133
X- and W-band EPR spectra, at room and low temperatures, are reported for nitroxide spin labels attached to cysteine residues selectively introduced into two proteins, the DNase domain of colicin-E9...
2.
Pommer A, Cal S, Keeble A, Walker D, Evans S, Kuhlmann U, et al.
J Mol Biol
. 2001 Dec;
314(4):735-49.
PMID: 11733993
Colicin endonucleases and the H-N-H family of homing enzymes share a common active site structural motif that has similarities to the active sites of a variety of other nucleases such...
3.
Kleanthous C, Walker D
Trends Biochem Sci
. 2001 Oct;
26(10):624-31.
PMID: 11590016
Immunity proteins are high affinity inhibitors of colicins--SOS-induced toxins released by bacteria during times of stress. Recent work has shown that nuclease-specific immunity proteins are exosite inhibitors, binding adjacent to...
4.
Gorski S, Capaldi A, Kleanthous C, Radford S
J Mol Biol
. 2001 Sep;
312(4):849-63.
PMID: 11575937
The helical bacterial immunity proteins Im7 and Im9 have been shown to fold via kinetic mechanisms of differing complexity, despite having 60 % sequence identity. At pH 7.0 and 10...
5.
Paget M, Bae J, Hahn M, Li W, Kleanthous C, Roe J, et al.
Mol Microbiol
. 2001 Mar;
39(4):1036-47.
PMID: 11251822
In the Gram-positive bacterium, Streptomyces coelicolor A3(2), expression of the thioredoxin system is modulated by a sigma factor called sigmaR in response to changes in the cytoplasmic thiol-disulphide status, and...
6.
Ferguson N, Li W, Capaldi A, Kleanthous C, Radford S
J Mol Biol
. 2001 Mar;
307(1):393-405.
PMID: 11243827
To address the role of sequence in the folding of homologous proteins, the folding and unfolding kinetics of the all-helical bacterial immunity proteins Im2 and Im9 were characterised, together with...
7.
Capaldi A, Shastry M, Kleanthous C, Roder H, Radford S
Nat Struct Biol
. 2001 Jan;
8(1):68-72.
PMID: 11135674
Many proteins populate partially organized structures during folding. Since these intermediates often accumulate within the dead time (2-5 ms) of conventional stopped-flow and quench-flow devices, it has been difficult to...
8.
Carr S, Walker D, James R, Kleanthous C, Hemmings A
Acta Crystallogr D Biol Crystallogr
. 2000 Nov;
56(Pt 12):1630-3.
PMID: 11092930
The complex between the ribonuclease domain of the ribosome-inactivating colicin E3 and its protein inhibitor, the cognate immunity Im3, has been crystallized and preliminary X-ray characterization has been performed. Single...
9.
Penfold C, Hemmings A, MOORE G, Kleanthous C, James R
Mol Microbiol
. 2000 Nov;
38(3):639-49.
PMID: 11069686
The mechanism by which E colicins recognize and then bind to BtuB receptors in the outer membrane of Escherichia coli cells is a poorly understood first step in the process...
10.
Boetzel R, Czisch M, Kaptein R, Hemmings A, James R, Kleanthous C, et al.
Protein Sci
. 2000 Oct;
9(9):1709-18.
PMID: 11045617
The bacterial toxin colicin E9 is secreted by producing Escherichia coli cells with its 9.5 kDa inhibitor protein Im9 bound tightly to its 14.5 kDa C-terminal DNase domain. Double- and...