J R Apgar
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Explore the profile of J R Apgar including associated specialties, affiliations and a list of published articles.
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20
Citations
452
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Recent Articles
1.
Nechansky A, Robertson M, Albrecht B, Apgar J, Kricek F
J Immunol
. 2001 May;
166(10):5979-90.
PMID: 11342613
The interaction between human IgE and its high affinity receptor, FcepsilonRI, is a critical event in mediating the allergic response. Aggregation of the alpha-chain of FcepsilonRI (FcepsilonRIalpha) occurs via cross-linking...
2.
Field K, Apgar J, Hong-Geller E, Siraganian R, Baird B, Holowka D
Mol Biol Cell
. 2000 Oct;
11(10):3661-73.
PMID: 11029062
Characterization of defects in a variant subline of RBL mast cells has revealed a biochemical event proximal to IgE receptor (Fc epsilon RI)-stimulated tyrosine phosphorylation that is required for multiple...
3.
Sano H, Hsu D, Yu L, Apgar J, Kuwabara I, Yamanaka T, et al.
J Immunol
. 2000 Aug;
165(4):2156-64.
PMID: 10925302
Galectin-3 is a beta-galactoside-binding protein implicated in diverse biological processes. We found that galectin-3 induced human monocyte migration in vitro in a dose-dependent manner, and it was chemotactic at high...
4.
Zuberi R, Apgar J, Chen S, Liu F
J Immunol
. 2000 Feb;
164(5):2667-73.
PMID: 10679107
IgE is present in airway secretions from human patients with allergic rhinitis and bronchial asthma. However, the contribution of IgE present locally to the overall airway inflammation is not well...
5.
Yao L, Janmey P, Frigeri L, Han W, Fujita J, Kawakami Y, et al.
J Biol Chem
. 1999 Jul;
274(28):19752-61.
PMID: 10391917
A fraction of Bruton's tyrosine kinase (Btk) co-localizes with actin fibers upon stimulation of mast cells via the high affinity IgE receptor (FcepsilonRI). In this study, a molecular basis of...
6.
Frigeri L, Apgar J
J Immunol
. 1999 Feb;
162(4):2243-50.
PMID: 9973500
Cross-linking of FcepsilonRI on rat basophilic leukemia (RBL) cells initiates a signaling cascade leading to degranulation of the cells and the release of inflammatory mediators. Inhibitors that disrupt microfilaments, such...
7.
Apgar J
J Cell Sci
. 1997 Mar;
110 ( Pt 6):771-80.
PMID: 9099951
Rat basophilic leukemia cells will adhere to and spread out on fibronectin coated surfaces in an integrin dependent manner. Adhesion and spreading on fibronectin leads to increased degranulation, inositol phosphate...
8.
Apgar J
Mol Biol Cell
. 1995 Jan;
6(1):97-108.
PMID: 7749199
Cross-linking of the immunoglobulin E receptor on rat basophilic leukemia (RBL)1 cells by multivalent antigen activates phosphatidylinositol (PI) kinase and phosphatidylinositol 4-phosphate (PIP) kinase leading to the increased production of...
9.
Apgar J
Mol Biol Cell
. 1994 Mar;
5(3):313-22.
PMID: 8049523
Crosslinking of the IgE receptor on rat basophilic leukemia (RBL) cells using the multivalent antigen DNP-BSA leads to a rapid and sustained increase in the filamentous actin content of the...
10.
ORourke A, Mescher M, Apgar J
Mol Immunol
. 1992 Nov;
29(11):1299-308.
PMID: 1328876
Aggregation of the IgE receptor on rat basophilic leukemia (RBL-2H3) cells triggers increased hydrolysis of polyphosphoinositides (PI), secretion of arachidonic acid (AA) and its metabolites, and degranulation to release 5-hydroxytryptamine....