A M ORourke
Overview
Explore the profile of A M ORourke including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
234
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Recent Articles
1.
ORourke A, Wang E, Salter-Cid L, Huang L, Miller A, Podar E, et al.
J Neural Transm (Vienna)
. 2007 Mar;
114(6):845-9.
PMID: 17393060
We have developed several series of potent and selective small molecule inhibitors of SSAO (AOC3/VAP-1) that also block trafficking of leukocytes to sites of inflammation. Blocking of SSAO-mediated leukocyte adhesion...
2.
Redpath S, Alam S, Lin C, ORourke A, Gascoigne N
J Immunol
. 1999 Jun;
163(1):6-10.
PMID: 10384091
Bacterial superantigens such as Staphylococcus aureus enterotoxin A (SEA) are very potent stimulators of T cells. They bind to the Vbeta region of the TCR and to MHC class II,...
3.
4.
ORourke A, Shao H, Kaye J
J Immunol
. 1998 Dec;
161(11):5800-3.
PMID: 9834054
LFA-1 is a beta2 integrin that plays well-characterized roles in adhesion of T lymphocytes to APC, T cell-mediated cytolysis, and leukocyte-endothelial cell interactions. Although it is clear that LFA-1 must...
5.
ORourke A, Escuro G, Feeney A
Immunogenetics
. 1998 Sep;
48(5):354-5.
PMID: 9745014
No abstract available.
6.
ORourke A, Webb S
Eur J Immunol
. 1998 Feb;
27(12):3253-8.
PMID: 9464813
Previous studies showed that activation of CD4+ T cells with mouse mammary tumor virus-encoded Mls(a) superantigens induces strong proliferative responses and interleukin-2 production but fails to elicit typical early T...
7.
Brunmark A, ORourke A
J Immunol
. 1997 Aug;
159(4):1676-85.
PMID: 9257828
Mature CD4+ T cells can undergo stable adhesion to isolated antigenic MHC complexes, and upon TCR engagement exhibit up-regulated adhesion to the integrin ligands fibronectin (FN) and intercellular adhesion molecule-1...
8.
Ybarrondo B, ORourke A, McCarthy J, Mescher M
Immunology
. 1997 Jun;
91(2):186-92.
PMID: 9227315
Stimulation of cloned cytotoxic T lymphocytes (CTL) with anti-T-cell receptor (TCR) monoclonal antibody (mAb) in solution resulted in rapid and sustained activation of adhesion to immobilized fibronectin (FN) but did...
9.
Anel A, ORourke A, Kleinfeld A, Mescher M
Eur J Immunol
. 1996 Oct;
26(10):2310-9.
PMID: 8898939
Tyrosine phosphorylation of proteins plays a central role in T cell activation. Mitogens or anti-receptor antibodies have been employed to study these signaling events, but the extent to which these...
10.
ORourke A, Lasam M
J Immunol
. 1995 Oct;
155(8):3839-46.
PMID: 7561090
Engagement of the TCR modulates the avidity of several receptors that play key roles in lymphocyte adhesion and/or signal transduction, including CD8, CD11a/CD18 (LFA-1), CD2, and several beta 1-integrins. Here,...