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J Philip Creamer

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Recent Articles
1.
Sarchi M, Clough C, Crosse E, Kim J, Baquero Galvis L, Aydinyan N, et al.
Blood Cancer Discov . 2024 Jun; 5(5):353-370. PMID: 38856693
Splicing factor SF3B1 mutations are frequent somatic lesions in myeloid neoplasms that transform hematopoietic stem cells (HSCs) by inducing mis-splicing of target genes. However, the molecular and functional consequences of...
2.
Creamer J, Luff S, Yu H, Sturgeon C
Stem Cell Res . 2022 May; 62:102808. PMID: 35569347
To achieve efficient, reproducible differentiation of human pluripotent stem cells (hPSCs) towards specific hematopoietic cell-types, a comprehensive understanding of the necessary cell signaling and developmental trajectories involved is required. Previous...
3.
Luff S, Creamer J, Valsoni S, Dege C, Scarfo R, Dacunto A, et al.
Nat Cell Biol . 2022 Apr; 24(5):616-624. PMID: 35484246
The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) is a major goal for regenerative medicine. During embryonic development, HSCs derive from haemogenic endothelium (HE) in...
4.
Reilly A, Creamer J, Stewart S, Stolla M, Wang Y, Du J, et al.
Cell Stem Cell . 2022 Mar; 29(4):577-592.e8. PMID: 35278369
Abnormal nuclear morphology is a hallmark of malignant cells widely used in cancer diagnosis. Pelger-Huët anomaly (PHA) is a common abnormality of neutrophil nuclear morphology of unknown molecular etiology in...
5.
Dege C, Fegan K, Creamer J, Berrien-Elliott M, Luff S, Kim D, et al.
Dev Cell . 2020 Mar; 53(2):229-239.e7. PMID: 32197069
Natural killer (NK) cells are a critical component of the innate immune system. However, their ontogenic origin has remained unclear. Here, we report that NK cell potential first arises from...
6.
Rong-Mullins X, Ravishankar A, McNeal K, Lonergan Z, Biega A, Creamer J, et al.
PLoS One . 2017 Nov; 12(11):e0187522. PMID: 29155836
S. cerevisiae from different environments are subject to a wide range of selective pressures, whether intentional or by happenstance. Chemicals classified by their application, such as herbicides, fungicides and antibiotics,...
7.
Creamer J, Dege C, Ren Q, Ho J, Valentine M, Druley T, et al.
Blood . 2017 Apr; 129(22):2988-2992. PMID: 28408465
The generation of hematopoietic stem cells from human pluripotent stem cells (hPSCs) is a major goal for regenerative medicine. Achieving this goal is complicated by our incomplete understanding of the...