J P Shockcor
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Explore the profile of J P Shockcor including associated specialties, affiliations and a list of published articles.
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18
Citations
87
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Recent Articles
1.
Holmes E, Shockcor J
Curr Opin Drug Discov Devel
. 2009 Aug;
3(1):72-8.
PMID: 19649840
(1)H-NMR spectroscopy has proved to be a powerful and efficient means of monitoring the interaction of pharmacological agents with cells and tissues. The application of this technique to biofluid analysis,...
2.
Nicholls A, Wilson I, Godejohann M, Nicholson J, Shockcor J
Xenobiotica
. 2006 Jul;
36(7):615-29.
PMID: 16864507
The metabolism of acetyl-labelled phenacetin-C2H3 was investigated in man following a single (150 mg) oral dose. Urine samples were collected at predose, 0-2 h and >2-4 h post-dose, and samples...
3.
Nicholls A, Holmes E, Lindon J, Shockcor J, Farrant R, Haselden J, et al.
Chem Res Toxicol
. 2001 Aug;
14(8):975-87.
PMID: 11511171
The systemic biochemical effects of oral hydrazine administration (dosed at 75, 90, and 120 mg/kg) have been investigated in male Han Wistar rats using metabonomic analysis of (1)H NMR spectra...
4.
Sidelmann U, Bjornsdottir I, Shockcor J, Hansen S, Lindon J, Nicholson J
J Pharm Biomed Anal
. 2001 Mar;
24(4):569-79.
PMID: 11272313
High resolution nuclear magnetic resonance (NMR) spectroscopy is a very powerful tool for the structural identification of xenobiotic metabolites in complex biological matrices such as plasma, urine and bile. However,...
5.
Shockcor J, Unger S, Savina P, Nicholson J, Lindon J
J Chromatogr B Biomed Sci Appl
. 2000 Nov;
748(1):269-79.
PMID: 11092604
The human in vivo metabolism of the HIV-1 reverse transcriptase inhibitor 5-chloro-1-(2',3'-dideoxy-3'-fluoro-erythro-pentofuranosyl)uracil (BW935U83) was studied using 19F NMR spectroscopy, directly coupled LC-NMR and LC-NMR-MS. The number and relative proportions of...
6.
Nicholls A, Lindon J, Farrant R, Shockcor J, Wilson I, Nicholson J
J Pharm Biomed Anal
. 2000 Apr;
20(6):865-73.
PMID: 10746955
The metabolism and futile deacetylation of phenacetin has been investigated in the rat via 1H NMR spectroscopic analysis of urine. Animals were dosed with either phenacetin or phenacetin-C2H3 and urine...
7.
Chen W, Shockcor J, Tonge R, Hunter A, Gartner C, Nelson S
Biochemistry
. 1999 Jul;
38(25):8159-66.
PMID: 10387061
N-acetyl-p-benzoquinone imine (NAPQI), a reactive metabolite of acetaminophen (APAP), can arylate and oxidize protein and nonprotein thiols in the pathogenesis of APAP-induced hepatotoxicity. We report the first direct evidence for...
8.
Nicholls A, Farrant R, Shockcor J, Unger S, Wilson I, Lindon J, et al.
J Pharm Biomed Anal
. 1997 Apr;
15(7):901-10.
PMID: 9160256
HPLC-NMR spectroscopy has been used to investigate the level of deacetylation followed by reacetylation (futile deacetylation) of metabolites of paracetamol detected in human and rat urine. This has been achieved...
9.
Shockcor J, Unger S, Wilson I, Foxall P, Nicholson J, Lindon J
Anal Chem
. 1996 Dec;
68(24):4431-5.
PMID: 8972626
The direct coupling of HPLC with NMR spectroscopy has been extended by splitting the HPLC eluent after conventional UV detection and sending part to a NMR spectrometer and part to...
10.
Shockcor J, Wurm R, Frick L, Sanderson P, Farrant R, Sweatman B, et al.
Xenobiotica
. 1996 Feb;
26(2):189-99.
PMID: 8868002
1. Human urine samples from a clinical trial of the anti-HIV compound (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-cyto sin e (BW524W91) have been analysed using 19F-nmr and 1H-hplc-nmr spectroscopy. 2. The identities and relative levels...