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J Nathans

Explore the profile of J Nathans including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 100
Citations 6889
Followers 0
Related Specialties
Science
Biochemistry
Neurology
Top 10 Co-Authors
J P Macke
H Sun
Y Wang
C H Sung
P M Smallwood
M Xiang
A Rattner
S L Merbs
L Zhou
C J Weitz
Published In
Proc Natl Acad Sci U S A
J Biol Chem
Science
Neuron
J Neurosci
Affiliations
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Recent Articles
1.
Climate change and the integrity of science
Gleick P, ADAMS R, Amasino R, Anders E, Anderson D, Anderson W, et al.
Science . 2010 May; 328(5979):689-90. PMID: 20448167
No abstract available.
2.
Mechanistic studies of ABCR, the ABC transporter in photoreceptor outer segments responsible for autosomal recessive Stargardt disease
Sun H, Nathans J
J Bioenerg Biomembr . 2002 Jan; 33(6):523-30. PMID: 11804194
ABCR is an ABC transporter that is found exclusively in vertebrate photoreceptor outer segments. Mutations in the human ABCR gene are responsible for autosomal recessive Stargardt disease, the most common...
3.
A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival
Rattner A, Smallwood P, Williams J, Cooke C, Savchenko A, Lyubarsky A, et al.
Neuron . 2001 Dec; 32(5):775-86. PMID: 11738025
A cadherin family member, prCAD, was identified in retina cDNA by subtractive hybridization and high throughput sequencing. prCAD is expressed only in retinal photoreceptors, and the prCAD protein is localized...
4.
Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2)
Ramulu P, Kennedy M, Xiong W, Williams J, Cowan M, Blesh D, et al.
Mol Cell Biol . 2001 Nov; 21(24):8605-14. PMID: 11713293
Rhodopsin dephosphorylation in Drosophila is a calcium-dependent process that appears to be catalyzed by the protein product of the rdgC gene. Two vertebrate rdgC homologs, PPEF-1 and PPEF-2, have been...
5.
The challenge of macular degeneration
Sun H, Nathans J
Sci Am . 2001 Sep; 285(4):68-75. PMID: 11570044
No abstract available.
6.
Four novel mutations in the RPE65 gene in patients with Leber congenital amaurosis
Simovich M, Miller B, Ezzeldin H, Kirkland B, McLeod G, Fulmer C, et al.
Hum Mutat . 2001 Jul; 18(2):164. PMID: 11462243
Leber congenital amaurosis (LCArpar; is a heterogeneous disorder representing the congenital forms of retinitis pigmentosa accounting for about 5% of all retinal dystrophies. The RPE65 gene product is required for...
7.
Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains
Dann C, Hsieh J, Rattner A, Sharma D, Nathans J, LEAHY D
Nature . 2001 Jul; 412(6842):86-90. PMID: 11452312
Members of the Frizzled family of seven-pass transmembrane proteins serve as receptors for Wnt signalling proteins. Wnt proteins have important roles in the differentiation and patterning of diverse tissues during...
8.
Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene
Wang Y, Huso D, Cahill H, Ryugo D, Nathans J
J Neurosci . 2001 Jun; 21(13):4761-71. PMID: 11425903
Wnt signaling has been implicated in the control of cell proliferation and in synapse formation during neural development, and these actions are presumed to be mediated by frizzled receptors. In...
9.
Cellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis elegans protein phosphatase with EF-hands
Ramulu P, Nathans J
J Biol Chem . 2001 Apr; 276(27):25127-35. PMID: 11312268
The RdgC/PPEF family of serine/threonine protein phosphatases is distinguished by the presence of C-terminal EF-hands and neuron-specific expression, including frequent expression in primary sensory neurons. Here we report that the...
10.
ABCR, the ATP-binding cassette transporter responsible for Stargardt macular dystrophy, is an efficient target of all-trans-retinal-mediated photooxidative damage in vitro. Implications for retinal disease
Sun H, Nathans J
J Biol Chem . 2001 Mar; 276(15):11766-74. PMID: 11278627
A large body of experimental and clinical data have documented the damaging effects of light exposure on photoreceptor cells although the identities of the biologically relevant molecular targets of photodamage...