C J Weitz
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Explore the profile of C J Weitz including associated specialties, affiliations and a list of published articles.
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23
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2277
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Recent Articles
1.
Sadacca L, Lamia K, deLemos A, Blum B, Weitz C
Diabetologia
. 2010 Oct;
54(1):120-4.
PMID: 20890745
Aims/hypothesis: Loss of circadian clocks from all tissues causes defective glucose homeostasis as well as loss of feeding and activity rhythms. Little is known about peripheral tissue clocks, so we...
2.
Storch K, Paz C, Signorovitch J, Raviola E, Pawlyk B, Li T, et al.
Cold Spring Harb Symp Quant Biol
. 2008 Apr;
72:307-18.
PMID: 18419288
Circadian clocks are widely distributed in mammalian tissues, but little is known about the physiological functions of clocks outside the suprachiasmatic nucleus of the brain. The retina has an intrinsic...
3.
Kramer A, Yang F, Snodgrass P, Li X, Scammell T, Davis F, et al.
Science
. 2001 Dec;
294(5551):2511-5.
PMID: 11752569
The circadian clock in the suprachiasmatic nucleus (SCN) is thought to drive daily rhythms of behavior by secreting factors that act locally within the hypothalamus. In a systematic screen, we...
4.
Griffin Jr E, Staknis D, Weitz C
Science
. 1999 Oct;
286(5440):768-71.
PMID: 10531061
Cryptochrome (CRY), a photoreceptor for the circadian clock in Drosophila, binds to the clock component TIM in a light-dependent fashion and blocks its function. In mammals, genetic evidence suggests a...
5.
Ceriani M, Darlington T, Staknis D, Mas P, Petti A, Weitz C, et al.
Science
. 1999 Jul;
285(5427):553-6.
PMID: 10417378
Most organisms have circadian clocks consisting of negative feedback loops of gene regulation that facilitate adaptation to cycles of light and darkness. In this study, CRYPTOCHROME (CRY), a protein involved...
6.
Sangoram A, Saez L, Antoch M, Gekakis N, Staknis D, Whiteley A, et al.
Neuron
. 1998 Dec;
21(5):1101-13.
PMID: 9856465
We report the cloning and mapping of mouse (mTim) and human (hTIM) orthologs of the Drosophila timeless (dtim) gene. The mammalian Tim genes are widely expressed in a variety of...
7.
Darlington T, Ceriani M, Staknis D, Gekakis N, Steeves T, Weitz C, et al.
Science
. 1998 Jun;
280(5369):1599-603.
PMID: 9616122
The circadian oscillator generates a rhythmic output with a period of about 24 hours. Despite extensive studies in several model systems, the biochemical mode of action has not yet been...
8.
Gekakis N, Staknis D, Nguyen H, Davis F, Wilsbacher L, King D, et al.
Science
. 1998 Jun;
280(5369):1564-9.
PMID: 9616112
The mouse Clock gene encodes a bHLH-PAS protein that regulates circadian rhythms and is related to transcription factors that act as heterodimers. Potential partners of CLOCK were isolated in a...
9.
Morris M, Viswanathan N, Kuhlman S, Davis F, Weitz C
Science
. 1998 Mar;
279(5356):1544-7.
PMID: 9488654
The mechanism by which mammalian circadian clocks are entrained to light-dark cycles is unknown. The clock that drives behavioral rhythms is located in the suprachiasmatic nucleus (SCN) of the brain,...
10.