J Moscat
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Explore the profile of J Moscat including associated specialties, affiliations and a list of published articles.
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76
Citations
2858
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Recent Articles
1.
Nayak R, Hegde S, Althoff M, Wellendorf A, Mohmoud F, Perentesis J, et al.
Nat Commun
. 2019 Jan;
10(1):46.
PMID: 30610188
Epigenetically regulated transcriptional plasticity has been proposed as a mechanism of differentiation arrest and resistance to therapy. BCR-ABL leukemias result from leukemic stem cell/progenitor transformation and represent an opportunity to...
2.
Moscat J, Diaz-Meco M, Wooten M
Cell Death Differ
. 2009 Aug;
16(11):1426-37.
PMID: 19713972
The recent identification of a novel protein-protein interaction module, termed PB1, in critical signaling molecules such as p62 (also known as sequestosome1), the atypical PKCs, and Par-6, has unveiled the...
3.
Moscat J, Rennert P, Diaz-Meco M
Cell Death Differ
. 2005 Dec;
13(5):702-11.
PMID: 16322752
The atypical protein kinase C (PKC) isoforms (aPKC) have been implicated in the regulation of a number of essential signaling events. Early studies using dominant-negative mutants suggested that they are...
4.
Leitges M, Sanz L, MARTIN P, Duran A, Braun U, Garcia J, et al.
Mol Cell
. 2001 Oct;
8(4):771-80.
PMID: 11684013
Here we have addressed the role that zetaPKC plays in NF-kappaB activation using mice in which this kinase was inactivated by homologous recombination. These mice, although grossly normal, showed phenotypic...
5.
Moscat J, Sanz L, Sanchez P, Diaz-Meco M
Adv Enzyme Regul
. 2001 Jun;
41:99-120.
PMID: 11384740
No abstract available.
6.
Moscat J, Diaz-Meco M
EMBO Rep
. 2001 Mar;
1(5):399-403.
PMID: 11258478
Since its discovery more than 10 years ago, the atypical PKC (aPKC) subfamily has attracted great interest. A number of reports have shown that the kinases of this subfamily play...
7.
Thomas G, De Pablo F, Schlessinger J, Moscat J
EMBO Rep
. 2001 Mar;
1(1):11-5.
PMID: 11256615
No abstract available.
8.
Wooten M, Seibenhener M, Mamidipudi V, Diaz-Meco M, Barker P, Moscat J
J Biol Chem
. 2001 Mar;
276(11):7709-12.
PMID: 11244088
Nerve growth factor (NGF) binding to both p75 and TrkA neurotrophin receptors activates the transcription factor nuclear factor kappaB (NF-kappaB). Here we show that the atypical protein kinase C-interacting protein,...
9.
Diaz-Meco M, Moscat J
Mol Cell Biol
. 2001 Feb;
21(4):1218-27.
PMID: 11158308
The MEK5-extracellular signal-regulated kinase (ERK5) tandem is a novel mitogen-activated protein kinase cassette critically involved in mitogenic activation by the epidermal growth factor (EGF). The atypical protein kinase C isoforms...
10.
Rust C, Karnitz L, Paya C, Moscat J, Simari R, Gores G
J Biol Chem
. 2000 Apr;
275(26):20210-6.
PMID: 10770953
Liver injury during cholestasis reflects a balance between the effects of toxic and nontoxic bile acids. However, the critical distinction between a toxic and nontoxic bile acid remains subtle and...