The Atypical Protein Kinase Cs. Functional Specificity Mediated by Specific Protein Adapters

Overview

Journal EMBO Rep

Specialty Molecular Biology

Date 2001 Mar 22

PMID 11258478

Citations 70

Authors

J Moscat

M T Diaz-Meco

Affiliations

Soon will be listed here.

Abstract

Since its discovery more than 10 years ago, the atypical PKC (aPKC) subfamily has attracted great interest. A number of reports have shown that the kinases of this subfamily play critical roles in signaling pathways that control cell growth, differentiation and survival. Recently, several investigators have identified a number of aPKC-interacting proteins whose characterization is helping to unravel the mechanisms of action and functions of these kinases. These interactors include p62, Par-6, MEK5 and Par-4. The details of how these adapters serve to link the aPKCs to different receptor signaling pathways and substrates in response to specific stimuli are crucial not only for developing an understanding of the roles and functions of the aPKCs themselves, but also for more generally establishing a view of how specificity in signal transduction is achieved.

Citing Articles

Protein Kinases and their Inhibitors Implications in Modulating Disease Progression.

Ahsan R, Muazzam Khan M, Mishra A, Noor G, Ahmad U Protein J. 2023; 42(6):621-632.

PMID: 37768476 DOI: 10.1007/s10930-023-10159-9.

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.

Malik A, Karapetsas A, Nirujogi R, Chatterjee D, Phung T, Wightman M Biochem J. 2022; 479(18):1941-1965.

PMID: 36040231 PMC: 9555798. DOI: 10.1042/BCJ20220308.

Protein kinase Cλ/ι in cancer: a contextual balance of time and signals.

Moscat J, Linares J, Duran A, Diaz-Meco M Trends Cell Biol. 2022; 32(12):1023-1034.

PMID: 35501226 PMC: 9716658. DOI: 10.1016/j.tcb.2022.04.002.

Molecular events in neuroendocrine prostate cancer development.

Wang Y, Wang Y, Ci X, Choi S, Crea F, Lin D Nat Rev Urol. 2021; 18(10):581-596.

PMID: 34290447 PMC: 10802813. DOI: 10.1038/s41585-021-00490-0.

Retinal Physiology and Circulation: Effect of Diabetes.

Wright W, Eshaq R, Lee M, Kaur G, Harris N Compr Physiol. 2020; 10(3):933-974.

PMID: 32941691 PMC: 10088460. DOI: 10.1002/cphy.c190021.

References

Guo Q, Fu W, Xie J, Luo H, Sells S, Geddes J . Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease. Nat Med. 1998; 4(8):957-62. DOI: 10.1038/nm0898-957. View

Sanchez P, de Carcer G, Sandoval I, Moscat J, Diaz-Meco M . Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Mol Cell Biol. 1998; 18(5):3069-80. PMC: 110686. DOI: 10.1128/MCB.18.5.3069. View

Izumi Y, Hirose T, Tamai Y, Hirai S, Nagashima Y, Fujimoto T . An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. J Cell Biol. 1998; 143(1):95-106. PMC: 2132825. DOI: 10.1083/jcb.143.1.95. View

Takeda H, Matozaki T, Takada T, Noguchi T, Yamao T, Tsuda M . PI 3-kinase gamma and protein kinase C-zeta mediate RAS-independent activation of MAP kinase by a Gi protein-coupled receptor. EMBO J. 1999; 18(2):386-95. PMC: 1171133. DOI: 10.1093/emboj/18.2.386. View

Lallena M, Diaz-Meco M, Bren G, Paya C, Moscat J . Activation of IkappaB kinase beta by protein kinase C isoforms. Mol Cell Biol. 1999; 19(3):2180-8. PMC: 84010. DOI: 10.1128/MCB.19.3.2180. View

Wang C, Cusack Jr J, Liu R, Baldwin Jr A . Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nat Med. 1999; 5(4):412-7. DOI: 10.1038/7410. View

Lomaga M, Yeh W, Sarosi I, Duncan G, Furlonger C, Ho A . TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 1999; 13(8):1015-24. PMC: 316636. DOI: 10.1101/gad.13.8.1015. View

Sanz L, Sanchez P, Lallena M, Diaz-Meco M, Moscat J . The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. EMBO J. 1999; 18(11):3044-53. PMC: 1171386. DOI: 10.1093/emboj/18.11.3044. View

Diaz-Meco M, Lallena M, Monjas A, Frutos S, Moscat J . Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis. J Biol Chem. 1999; 274(28):19606-12. DOI: 10.1074/jbc.274.28.19606. View

10.

Thomas J, Allen J, Tsen M, Dubnicoff T, Danao J, Liao X . Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J Immunol. 1999; 163(2):978-84. View

11.

Goeddel D . Signal transduction by tumor necrosis factor: the Parker B. Francis Lectureship. Chest. 1999; 116(1 Suppl):69S-73S. DOI: 10.1378/chest.116.suppl_1.69s. View

12.

Kamakura S, Moriguchi T, Nishida E . Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem. 1999; 274(37):26563-71. DOI: 10.1074/jbc.274.37.26563. View

13.

Karin M . The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation. J Biol Chem. 1999; 274(39):27339-42. DOI: 10.1074/jbc.274.39.27339. View

14.

Wooten M . Function for NF-kB in neuronal survival: regulation by atypical protein kinase C. J Neurosci Res. 1999; 58(5):607-11. DOI: 10.1002/(sici)1097-4547(19991201)58:5<607::aid-jnr1>3.0.co;2-m. View

15.

Barradas M, Monjas A, Diaz-Meco M, Serrano M, Moscat J . The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. EMBO J. 1999; 18(22):6362-9. PMC: 1171699. DOI: 10.1093/emboj/18.22.6362. View

16.

Sanz L, Diaz-Meco M, Nakano H, Moscat J . The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J. 2000; 19(7):1576-86. PMC: 310227. DOI: 10.1093/emboj/19.7.1576. View

17.

Wooten M, Seibenhener M, Neidigh K, Vandenplas M . Mapping of atypical protein kinase C within the nerve growth factor signaling cascade: relationship to differentiation and survival of PC12 cells. Mol Cell Biol. 2000; 20(13):4494-504. PMC: 85825. DOI: 10.1128/MCB.20.13.4494-4504.2000. View

18.

Qiu R, Abo A, Martin G . A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation. Curr Biol. 2000; 10(12):697-707. DOI: 10.1016/s0960-9822(00)00535-2. View

19.

Joberty G, Petersen C, Gao L, Macara I . The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol. 2000; 2(8):531-9. DOI: 10.1038/35019573. View

20.

Wodarz A, Ramrath A, Grimm A, Knust E . Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J Cell Biol. 2000; 150(6):1361-74. PMC: 2150710. DOI: 10.1083/jcb.150.6.1361. View