J Magram
Overview
Explore the profile of J Magram including associated specialties, affiliations and a list of published articles.
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39
Citations
2382
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Recent Articles
1.
Wu C, Wang X, Gadina M, Oshea J, Presky D, Magram J
J Immunol
. 2000 Nov;
165(11):6221-8.
PMID: 11086056
Two subunits of the IL-12 receptor (IL-12R), IL-12R beta 1 and IL-12R beta 2, have been identified and cloned. Previous studies demonstrated that the IL-12R beta 1 subunit was required...
2.
Grimsby J, Coffey J, Dvorozniak M, Magram J, Li G, Matschinsky F, et al.
J Biol Chem
. 2000 Mar;
275(11):7826-31.
PMID: 10713097
The glucokinase regulatory protein (GKRP) inhibits glucokinase competitively with respect to glucose by forming a protein-protein complex with this enzyme. The physiological role of GKRP in controlling hepatic glucokinase activity...
3.
Trembleau S, Penna G, Gregori S, Chapman H, Serreze D, Magram J, et al.
J Immunol
. 1999 Aug;
163(5):2960-8.
PMID: 10453045
IL-12 and IL-12 antagonist administration to nonobese diabetic (NOD) mice accelerates and prevents insulin-dependent diabetes mellitus (IDDM), respectively. To further define the role of endogenous IL-12 in the development of...
4.
Rakhit A, Yeon M, Ferrante J, Fettner S, Nadeau R, Motzer R, et al.
Clin Pharmacol Ther
. 1999 Jul;
65(6):615-29.
PMID: 10391667
Background: Interleukin-12 (IL-12) is a cytokine that promotes type-1 helper T-cell responses and may have therapeutic utility in the treatment of cancer, asthma, and a variety of infectious diseases. Methods:...
5.
Wang X, Wilkinson V, Podlaski F, Wu C, Stern A, Presky D, et al.
Eur J Immunol
. 1999 Jun;
29(6):2007-13.
PMID: 10382764
Interleukin-12 (IL-12) is a heterodimeric cytokine composed of two disulfide-bonded subunits, p35 and p40, which has important regulatory effects on T cells and natural killer (NK) cells. In contrast to...
6.
Brombacher F, Dorfmuller A, Magram J, Dai W, Kohler G, Wunderlin A, et al.
Int Immunol
. 1999 Apr;
11(3):325-32.
PMID: 10221644
We have studied IL-12p35-deficient (IL-12p35(-/-)) mice to evaluate the role of IL-12 in resistance against Listeria monocytogenes. In the absence of bioactive IL-12p75, mutant mice acquired higher bacterial organ burden...
7.
Decken K, Kohler G, Wunderlin A, Mattner F, Magram J, Gately M, et al.
Infect Immun
. 1998 Sep;
66(10):4994-5000.
PMID: 9746609
To analyze the roles of interleukin-12 (IL-12) and the IL-12-dependent Th1 response in resistance to Cryptococcus neoformans, we have established a chronic infection model in wild-type mice and in mice...
8.
Wakeham J, Wang J, Magram J, Croitoru K, Harkness R, Dunn P, et al.
J Immunol
. 1998 Jun;
160(12):6101-11.
PMID: 9637527
Understanding of key cytokines and the nature of protective immune responses in pulmonary mycobacterial diseases remains a task of paramount importance. In this study, both wild-type (wt) and IL-12-deficient (IL-12(-/-))...
9.
Gately M, Renzetti L, Magram J, Stern A, Adorini L, Gubler U, et al.
Annu Rev Immunol
. 1998 May;
16:495-521.
PMID: 9597139
Interleukin-12 (IL-12) is a heterodimeric cytokine that plays a central role in promoting type 1 T helper cell (Th1) responses and, hence, cell-mediated immunity. Its activities are mediated through a...
10.
Piccotti J, Li K, Chan S, Ferrante J, Magram J, Eichwald E, et al.
J Immunol
. 1998 May;
160(3):1132-8.
PMID: 9570526
IL-12p70, a 70- to 75-kDa heterodimer consisting of disulfide-bonded 35-kDa (p35) and 40-kDa (p40) subunits, enhances Th1 development primarily by its ability to induce IFN-gamma production by NK and Th1...